
- Order number: 18290
Note: On October 1st 2021 all SMALP products in this kit were renamed. Nothing... more
Product information "Synthetic Nanodisc Screening Kit MINI, (8x2x50 mg)"

Note: On October 1st 2021 all SMALP products in this kit were renamed. Nothing else has changed. More on this renaming can be found here:
Finding the best performing synthetic nanodisc polymer for your respective nanodisc can be tricky. Especially if you have never worked with your current membrane protein of interest before. For these cases we at Cube Biotech compiled our most prominent SMALP and DIBMA products into this practical Synthetic Nanodisc Screening Set for your convenience!
All 8 products are buffered in HEPES to provide maximal comparability between the individual screening assays. Which 8 products are include in the Kit precisely can be found in the product's description.
Figure 1 shows the necessity for a SMALP screen instead of using a random SMALP product. Note that the detergent LMNG may provide the mighest protein yield, but it has to be added to the purified protein constantly and it might interfere with the SPIKE protein's function.
All 8 products are buffered in HEPES to provide maximal comparability between the individual screening assays. Which 8 products are include in the Kit precisely can be found in the product's description.
Figure 1 shows the necessity for a SMALP screen instead of using a random SMALP product. Note that the detergent LMNG may provide the mighest protein yield, but it has to be added to the purified protein constantly and it might interfere with the SPIKE protein's function.

Included SMALP Products
Feature | SMALP 140 | SMALP 140-I | SMALP 200 | SMALP 300 |
Polymer styrene-to-maleic-anhydride ratio [n:m] | 1.4:1 | 1.4:1 | 2:1 | 3:1 |
Molecular weight | 5,000 Da | 5,000 Da | 6,500 Da | 10,000 Da |
Form | Lyophilized powder | Lyophilized powder | Lyophilized powder | Lyophilized powder |
pH, after solving | 7.5 | 7.5 | 7.5 | 7.5 |
Divalent cationic tolerance | < 5 mM | < 100 mM | < 5 mM | < 5 mM |
Color | Amber | Brownish | Yellowish | Colorless |
Odor | Odorless | Odorless | Odorless | Odorless |
Other noteworthy feature | is imidized with DMAPA | Most commonly used SMA |
Included DIBMA Products
Feature | DIBMA 10 | DIBMA 12 | DIBMA Glycerol | DIBMA Glucosamine |
Formula Weight | 10,000 Da | 12,000 Da | 10,000 Da | 10,000 Da |
Solubility | > 10 % in H2O | |||
Absorbance at 280 nm | < 0.3 (1 % solution) | |||
Mg2+ Tolerance | 25 mM | 25 mM | >50 mM | >50 mM |
Ca2+ Tolerance | starts to precipitate 50 mM | starts to precipitate at 50 mM | >50 mM | >50 mM |
Related links to "Synthetic Nanodisc Screening Kit MINI, (8x2x50 mg)"

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