SMALP 25010S
- Order number: 18200
The SMALP products have been developed for biomedical purposes, in particular, for the... more
Product information "SMALP 25010S"
The SMALP products have been developed for biomedical purposes, in particular, for the solubilization of (biological) lipid membranes and isolation & purification of integral membrane proteins.
After solving the SMA + buffer powder in water, the product is ready-to-use. It can primarily used for all cell membrane hosts, including bacteria, yeast and human cells.
After successfull solubilization of the membrane protein of interest, the protein can be purified using affinity chromatography. We recommend the Rho1D4-tag for membrane protein purification and offer matching products for this purpose.
SMALP Screening: Different membrane protein may perform better with different SMAs variants. To ease your screening process we compiled all of our SMAs into a convenient SMALP Screening Set.
If you also like to compare SMA to DIBMA in the formation of your synthetic nanodiscs, we also offer our, that combines both our SMA and DIBMA products.
After solving the SMA + buffer powder in water, the product is ready-to-use. It can primarily used for all cell membrane hosts, including bacteria, yeast and human cells.
After successfull solubilization of the membrane protein of interest, the protein can be purified using affinity chromatography. We recommend the Rho1D4-tag for membrane protein purification and offer matching products for this purpose.
SMALP Screening: Different membrane protein may perform better with different SMAs variants. To ease your screening process we compiled all of our SMAs into a convenient SMALP Screening Set.
If you also like to compare SMA to DIBMA in the formation of your synthetic nanodiscs, we also offer our, that combines both our SMA and DIBMA products.
Features
| State | Lyophilized Powder, to be solved with water |
| Polymer styrene-to-maleic anhydride ratio | 3:1 |
| Molecular weight | 10.000 |
| pH after solving | 7.5 |
| Solubility | 35% |
| Divalent cationic tolerance | > 5 mM |
| Color | Colorless |
| Odor | Odorless |
| Freeze-thaw stable? | Yes |
| Storage | 4°C for long-term |
| Structure |  |
Figure 1: Western Blot of a purified membrane protein after stabilization through SMA. Reproduced with permission from Ms S. Nestorow, University of Birmingham.
Our protocol video that shows a full solubilization process using SMALP
Disclaimer
The use of styrene maleic anhydride copolymer (SMA) products for the manufacturing of styrene maleic acid copolymer - lipid particles (nanodiscs) (SMALP), and the use of SMALP, are covered by one or more of the following patents owned by Malvern Cosmeceutics Limited: US8623414, EP1890675, GB2426703, AU2006253886, JP5142898, IN261468, CN ZL200680018957.2, CA 2611144 and by the University of Birmingham US8754168.
The purchaser is licensed under those patents to use the SMA for the manufacture of SMALPs and to use SMALPs so manufactured for the purpose of research and development of proteins, including their production (including purification and solubilization), screening, testing, analysis, characterization (including structural analysis and characterization), including for the purpose of drug screening, but not for the purpose of delivery of agents to humans or other animals for therapeutic, diagnostic, prophylactic purposes, which uses are specifically prohibited.
The purchaser is licensed under those patents to use the SMA for the manufacture of SMALPs and to use SMALPs so manufactured for the purpose of research and development of proteins, including their production (including purification and solubilization), screening, testing, analysis, characterization (including structural analysis and characterization), including for the purpose of drug screening, but not for the purpose of delivery of agents to humans or other animals for therapeutic, diagnostic, prophylactic purposes, which uses are specifically prohibited.
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