SMALP Screening Set (4x3x50 mg)

SMALP Screening Set (4x3x50 mg)
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Membrane protein and their composition as as versatile as the whole cell membrane itself.... more
Product information "SMALP Screening Set (4x3x50 mg)"
Membrane protein and their composition as as versatile as the whole cell membrane itself. For this reason it is sadly impossible to predict with a 100% accuracy which SMALP product is suited best for the solubilization & subsequent of your membrane protein of interest.
For this reason we offer this SMALP Screening Kit that consists of our four individual SMAs. This way you have a convenient way to screen for the best SMA for your protein before scaling up your assay.
In case you would like to extend your polymer screening beyond the reaches of SMA we offer our Synthetic Nanodisc Screening Kit, that covers both SMA and DIBMA.

Figure 1 shows the necessity for a SMALP screen instead of using a random SMALP product. Note that the detergent LMNG may provide the mighest protein yield, but it has to be added to the purified protein constantly and it might interfere with the SPIKE protein's function.
SPIKE COV-2 in SMA Figure 1: Example of a SMALP screening assay. Different SMALPs compared in after solubilisation & purification of Rho1-tagged SPIKE protein of coronavirus.

Our SMALP Screening Set consits off the following four individual products:

Feature SMALP
1100I
SMALP
25010S
SMALP
30010S
SMALP
40005S
Polymer styrene-to-maleic-anhydride ratio [n:m] 1.4:1 3:1 2.3:1 1.4:1
Molecular weight 5,000 Da 10,000 Da 6,500 Da 5,000 Da
Form Lyophilized powder Lyophilized powder Lyophilized powder Lyophilized powder
pH 5.5-6.5 7.8-8.2 6.8-7.2 5.0-6.0
Divalent cationic tolerance < 100 mM < 5 mM < 5 mM < 5 mM
Color Brownish Colorless Yellowish Amber
Odor Odorless Odorless Odorless Odorless
Other noteworthy feature is imidized with DMAPA   Most commonly used SMA  
Western Blot using SMALPS Figure 2: Western Blot of a purified membrane protein after stabilization through SMA.
Reproduced with permission from Ms S. Nestorow, University of Birmingham.

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Disclaimer

The use of styrene maleic anhydride copolymer (SMA) products for the manufacturing of styrene maleic acid copolymer - lipid particles (nanodiscs) (SMALP), and the use of SMALP, are covered by one or more of the following patents owned by Malvern Cosmeceutics Limited: US8623414, EP1890675, GB2426703, AU2006253886, JP5142898, IN261468, CN ZL200680018957.2, CA 2611144 and by the University of Birmingham US8754168.

The purchaser is licensed under those patents to use the SMA for the manufacture of SMALPs and to use SMALPs so manufactured for the purpose of research and development of proteins, including their production (including purification and solubilization), screening, testing, analysis, characterization (including structural analysis and characterization), including for the purpose of drug screening, but not for the purpose of delivery of agents to humans or other animals for therapeutic, diagnostic, prophylactic purposes, which uses are specifically prohibited.
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