Need pure, active, wild-type membrane proteins - in nanodiscs?
, in particular GPCRs, are the most pharmaceutically relevant protein class. At the same time, it is very difficult to obtain them in pure, active form. Cube Biotech's protein experts have worked hard to produce human GPCRs and other membrane proteins in sufficient quality that we can now offer to the community. GPCRs are both available solubilized in detergent, or reconstituted into nanodiscs for stabilization.
Colored membrane proteins are available that can be used as controls in protein crystallization, and biochemical/biophysical assays.
Whether you are planning to perform biophysical or biochemical experiments with the currently offered target proteins, or simply use them as positive controls to set up your targets of interest, we will be happy to discuss the quantities you need.
Pure & Active membrane proteins from Cube Biotech were successfully used in the following publications:
|Protein||Target Name||Origin||Form of solubilization / stabilization|
|GPBAR1/TGR5 ||G-protein coupled bile receptor 1 ||Human ||Detergent |
|GLP1R ||Glucagon-like peptide receptor 1 ||Human ||Detergent |
|OPRM1 ||Mu-type opioid receptor ||Human ||Nanodisc |
|NTSR1 ||Neurotensin receptor type 1 ||Human ||Detergent |
|VGT ||Vesicular glutamate transporter 2 ||Human || |
|BR ||Bacteriorhodopsin ||Halobacterium salinarum ||Detergent |
|HsSR-1 ||Sensory rhodopsin-1 ||Halobacterium salinarum ||Detergent |
|HsSR-2 ||Sensory rhodopsin-2 ||Halobacterium salinarum ||Detergent |
|NpSR-2 ||Sensory rhodopsin-2 ||Natronomonas pharaonis ||Detergent |
|CaChR1 ||Channelrhodopsin 1 ||Chloromonas augustae ||Detergent |
|MC4R ||Melanocortin receptor 4 ||Homo sapiens ||Detergent |
|AChR ||Acetylcholin receptor 1 ||Torpedo Californica || |