Pure & Active Membrane Proteins

Membrane proteins, in particular GPCRs, are the most pharmaceutically relevant protein class. At the same time, it is very difficult to obtain them in pure, active form. Cube Biotech's protein experts have worked hard to produce human GPCRs and other membrane proteins in sufficient quality that we can now offer to the community. GPCRs are both available solubilized in detergent, or reconstituted into nanodiscs for stabilization.

Whether you are planning to perform biophysical or biochemical experiments with the currently offered target proteins, or simply use them as positive controls to set up your targets of interest, we will be happy to discuss the quantities you need.

Pure & Active membrane proteins from Cube Biotech were successfully used in the following publications:

Protein	Target Name	Origin	Form of solubilization / stabilization
GPBAR1/TGR5	G-protein coupled bile receptor 1	Human	Detergent
GLP1R	Glucagon-like peptide receptor 1	Human	Detergent
OPRM1	Mu-type opioid receptor	Human	Nanodisc
NTSR1	Neurotensin receptor type 1	Human	Detergent
VGT	Vesicular glutamate transporter 2	Human
BR	Bacteriorhodopsin	Halobacterium salinarum	Detergent
HsSR-1	Sensory rhodopsin-1	Halobacterium salinarum	Detergent
HsSR-2	Sensory rhodopsin-2	Halobacterium salinarum	Detergent
NpSR-2	Sensory rhodopsin-2	Natronomonas pharaonis	Detergent
CaChR1	Channelrhodopsin 1	Chloromonas augustae	Detergent
MC4R	Melanocortin receptor 4	Homo sapiens	Detergent
AChR	Acetylcholin receptor 1	Torpedo Californica