ACE2 receptor (Ectodomain)

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ACE2 (Angiotensin-converting enzyme 2) is the gateway of the coronavirus SARS-CoV-2 into our... more
Product information "ACE2 receptor (Ectodomain)"
ACE2 (Angiotensin-converting enzyme 2) is the gateway of the coronavirus SARS-CoV-2 into our cell. Its actual cellular function is that of a cell surface-bound carboxypeptidase. We provide you with the Ectodomain of ACE2, ready for ligand binding studies, crystallization, and other biochemical/biophysical experiments.

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SPIKE in MSP nanodisc, Gel filtrationSDS-PAGE and subsequent western blot showing the Ectodomain of ACE2. The His-tagged protein was purified using INDIGO-Ni agarose.
ELISA binding assay ACE2 ectodomainThe ACE2 ectodomain was immobilized at a concentration of 500 ng per well, the trimeric CoV-2 spike protein was used in triplicates at concentrations between 1 x 10-9M and 2 x 10-5M. The apparent KD value is approx. 2x 10-8M.

Features

 
Protein ACE2 (Angiotensin-converting enzyme 2)
Alternative names Angiotensin-converting enzyme homolog (ACEH); Angiotensin-converting enzyme-related carboxypeptidase (ACE-related carboxypeptidase);
UniProt number Q9BYF1
Protein classes Single span transmembrane protein, Carboxypeptidase
Organism Human (Homo sapiens)
Sequence

Ectodomain (AA 1 – 740), wildtype sequence and C-terminal 6 x His tag (red)


MSSSSWLLLS LVAVTAAQST IEEQAKTFLD KFNHEAEDLF YQSSLASWNY NTNITEENVQ NMNNAGDKWS AFLKEQSTLA QMYPLQEIQN LTVKLQLQAL QQNGSSVLSE DKSKRLNTIL NTMSTIYST GKVCNPDNPQ ECLLLEPGLN EIMANSLDYN ERLWAWESWR SEVGKQLRPL Y EEYVVLKN EMARANHYED YGDYWRGDYE VNGVDGYDYS RGQLIEDVEH TFEEIKPLYE HL HAYVRAK LMNAYPSYIS PIGCLPAHLL GDMWGRFWTNL YSLTVPFGQKP NIDVTDAMVD Q AWDAQRIF KEAEKFFVSV GLPNMTQGFWE NSMLTDPGNV QKAVCHPTAW DLGKGDFRIL M CTKVTMDD FLTAHHEMGH IQYDMAYAAQP FLLRNGANEG FHEAVGEIMS LSAATPKHLK S IGLLSPDF QEDNETEINF LLKQALTIVG TLPFTYMLE KWRWMVFKG EIPKDQWMKK WWEM KREIV GVVEPVPHD ETYCDPASLF HVSNDYSFIR YYTRTLYQFQ FQEALCQAA KHEGPLH KC DISNSTEAGQ KLFNMLRLGK SEPWTLALE NVVGAKNMNV RPLLNYFEPL FTWLKDQNK NSFVGWSTDW SPYADQSIKV RISLKSALGD KAYEWNDNEM YLFRSSVAYA MRQYFLKVKN QMILFGEED VRVANLKPRI SFNFFVTAPK NVSDIIPRTE VEKAIRMSRS RINDAFRLND N SLEFLGIQ PTLGPPNQPP VSHHHHHH

Affinity tags C-terminal His-tag
Size (excluding additional elements) 86,1 kDa
Expression system Hek293 mammalia cells
Purified via Ni-INDIGO Agarose and Size Exclusion Chromatograpy
Buffer 20 mM Hepes, 100 mM NaCl; pH 7.4
Purity (SDS-PAGE) >95 % as determined by SDS-PAGE
Homogeneity Size exclusion chromatography
Function Host cell receptor for virus entry, Protease
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