ACE2 receptor (Ectodomain)

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ACE2 (Angiotensin-converting enzyme 2) is the gateway of the coronavirus SARS-CoV-2 into our... more

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Product information "ACE2 receptor (Ectodomain)"

ACE2 (Angiotensin-converting enzyme 2) is the gateway of the coronavirus SARS-CoV-2 into our cell. Its actual cellular function is that of a cell surface-bound carboxypeptidase. We provide you with the Ectodomain of ACE2, ready for ligand binding studies, crystallization, and other biochemical/biophysical experiments.

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SDS-PAGE and subsequent western blot showing the Ectodomain of ACE2. The His-tagged protein was purified using INDIGO-Ni agarose.

Features

Protein	ACE2 (Angiotensin-converting enzyme 2)
Alternative names	Angiotensin-converting enzyme homolog (ACEH); Angiotensin-converting enzyme-related carboxypeptidase (ACE-related carboxypeptidase);
UniProt number	Q9BYF1
Protein classes	Single span transmembrane protein, Carboxypeptidase
Organism	Human (Homo sapiens)
Sequence	Ectodomain (AA 1 – 740), wildtype sequence and C-terminal 6 x His tag (red) MSSSSWLLLS LVAVTAAQST IEEQAKTFLD KFNHEAEDLF YQSSLASWNY NTNITEENVQ NMNNAGDKWS AFLKEQSTLA QMYPLQEIQN LTVKLQLQAL QQNGSSVLSE DKSKRLNTIL NTMSTIYST GKVCNPDNPQ ECLLLEPGLN EIMANSLDYN ERLWAWESWR SEVGKQLRPL Y EEYVVLKN EMARANHYED YGDYWRGDYE VNGVDGYDYS RGQLIEDVEH TFEEIKPLYE HL HAYVRAK LMNAYPSYIS PIGCLPAHLL GDMWGRFWTNL YSLTVPFGQKP NIDVTDAMVD Q AWDAQRIF KEAEKFFVSV GLPNMTQGFWE NSMLTDPGNV QKAVCHPTAW DLGKGDFRIL M CTKVTMDD FLTAHHEMGH IQYDMAYAAQP FLLRNGANEG FHEAVGEIMS LSAATPKHLK S IGLLSPDF QEDNETEINF LLKQALTIVG TLPFTYMLE KWRWMVFKG EIPKDQWMKK WWEM KREIV GVVEPVPHD ETYCDPASLF HVSNDYSFIR YYTRTLYQFQ FQEALCQAA KHEGPLH KC DISNSTEAGQ KLFNMLRLGK SEPWTLALE NVVGAKNMNV RPLLNYFEPL FTWLKDQNK NSFVGWSTDW SPYADQSIKV RISLKSALGD KAYEWNDNEM YLFRSSVAYA MRQYFLKVKN QMILFGEED VRVANLKPRI SFNFFVTAPK NVSDIIPRTE VEKAIRMSRS RINDAFRLND N SLEFLGIQ PTLGPPNQPP VSHHHHHH
Affinity tags	C-terminal His-tag
Size (excluding additional elements)	86,1 kDa
Expression system	Hek293 mammalia cells
Purified via	Ni-INDIGO Agarose and Size Exclusion Chromatograpy
Buffer	20 mM Hepes, 100 mM NaCl; pH 7.4
Purity (SDS-PAGE)	>95 % as determined by SDS-PAGE
Homogeneity	Size exclusion chromatography
Function	Host cell receptor for virus entry, Protease