SARS CoV-2 full-length Spike B.1.1.7 Mutation
- Order number: 28716
All viruses undergo fast mutations and adapt quickly to the countermeasures that the immune... more
Product information "SARS CoV-2 full-length Spike B.1.1.7 Mutation"
| Product Type: | Mutant Spike Protein |
| Protein Sequence: | Full-length |
All viruses undergo fast mutations and adapt quickly to the countermeasures that the immune systems creates. SARS-CoV-2 of the COVID-19 pandemic is no exception to this. During the pandemic multiple mutant strains arose. To help the sciencific community to combat these mutants Cube Biotech offers the SPIKE protein of the mutants in full-length and active in their native trimeric form, stabilized with the LMNG detergent.
This is the spike protein of the mutant strain B.1.1.7, also commonly known as the "UK / Great Britain mutant". Its individual mutations are listed in the "features" table below.
This is the spike protein of the mutant strain B.1.1.7, also commonly known as the "UK / Great Britain mutant". Its individual mutations are listed in the "features" table below.
Further SPIKE related products by Cube Biotech include:
Figure 1: Data from our lab regarding SPIKE stabilized in a detergent mycelle.
A: SDS-Page of purified SPIKE in detergent mycelle.
B: Western blot of Rho1d4 tagged SPIKE, originated from the SDS Page seen in "A".
- SPIKE of mutant strain B.1.1.7, also known as the "Alpha" in LMNG.
- SPIKE of mutant strain B.1.351, also known as the "Beta" in LMNG.
- SPIKE of mutant strain P.1, also known as the "Gamma" in LMNG.
- SPIKE of mutant strain B.1.617.2, also known as the "Delta" in LMNG.
- SPIKE of mutant strain B.1.429, also known as the "Epsilon" in LMNG. in LMNG.
- SPIKE of mutant strain B.1.525, also known as the "Eta" in LMNG. in LMNG.
- SPIKE of mutant strain B.1.621, also known as the "Mu" in LMNG. in LMNG.
- SPIKE of mutant strain B.1.1529, also known as the "Omicron" in LMNG. in LMNG.
- The "original" SPIKE protein in LMNG.
- The ectodomain of ACE2 - SPIKE's contact on the cell surface
- Anti-SPIKE antibodies
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Figure 1: Data from our lab regarding SPIKE stabilized in a detergent mycelle.A: SDS-Page of purified SPIKE in detergent mycelle.
B: Western blot of Rho1d4 tagged SPIKE, originated from the SDS Page seen in "A".
Features
| Alternative names | SPIKE_SARS2 Spike glycoprotein |
| UniProt number | P0DTC2 |
| Protein class | Single span transmembrane protein |
| Organism | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2) |
| Mutation that differ from "original" SPIKE protein | del 69-70 del 144 N501Y A570D D614G P681H T716I |
| Further modifications |
|
| Affinity tag | C-terminal Rho1D4 |
| Expression Host | Hek293 Expi cells |
| Size | 1286 amino acids (including Rho1D4 tag and linker) 142114 Da |
| Buffer composition | 20 mM Hepes pH 7.5; 150 mM NaCl, 0.001 % LMNG |
| Function | host cell surface receptor binding; fusion of virus membrane with host endosome membrane |
| Purity (SDS-PAGE) | >98% as determined by SDS-PAGE, see Fig. 1 A and B |
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