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All viruses undergo fast mutations and adept quickly to the countermeasures that the immune... more
Product information "SARS CoV-2 full-length Spike B.1.1.7 Mutation"
All viruses undergo fast mutations and adept quickly to the countermeasures that the immune systems creates against them. SARS-CoV-2 of the COVID-19 pandemic is no exception here. During the pandemic multiple mutant strains arose. To help the science combat these mutants Cube Biotech offers the SPIKE protein of these mutants in full-length and active in its native trimeric form, stabilized with the LMNG detergent.
This is the spike protein of the mutant strain B.1.1.7, also commonly known as the "UK / Great Britain mutant". Its individual mutations are listed in the "features" table below.
Further SPIKE related products by Cube Biotech include:
Figure 1: Data from our lab regarding SPIKE stabilized in a detergent mycelle.
A: SDS-Page of purified SPIKE in detergent mycelle.
B: Western blot of Rho1d4 tagged SPIKE, originated from the SDS Page seen in "A".
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A: SDS-Page of purified SPIKE in detergent mycelle.
B: Western blot of Rho1d4 tagged SPIKE, originated from the SDS Page seen in "A".
Features
Alternative names | SPIKE_SARS2 Spike glycoprotein |
UniProt number | P0DTC2 |
Protein class | Single span transmembrane protein |
Organism | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2) |
Mutation that differ from "original" SPIKE protein | del 69-70 del 144 N501Y A570D D614G P681H T716I S982A D1118H |
Further modifications |
|
Affinity tag | C-terminal Rho1D4 |
Expression Host | Hek293 Expi cells |
Size | 1286 amino acids (including Rho1D4 tag and linker) 142114 Da |
Buffer composition | 20 mM Hepes pH 7.5; 150 mM NaCl, 0.001 % LMNG |
Function | host cell surface receptor binding; fusion of virus membrane with host endosome membrane |
Purity (SDS-PAGE) | >98% as determined by SDS-PAGE, see Fig. 1 A and B |
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