All viruses undergo fast mutations and adept quickly to the countermeasures that the immune... more
Product information "SARS CoV-2 Spike B.1.351 Mutation RBD domain"
All viruses undergo fast mutations and adept quickly to the countermeasures that the immune systems creates against them. SARS-CoV-2 of the COVID-19 pandemic is no exception here. During the pandemic multiple mutant strains arose. To help the science combat these mutants Cube Biotech offers the RB-Domains of these mutant SPIKE proteins.
That is the full Receptor-Binding Domain of the SPIKE surface protein SARS-CoV-2 of the mutant strain B.1.351, also commonly known as the "SA / South Africa mutant". Its individual mutations are listed in the "features" table below.
Further SPIKE related products by Cube Biotech include:
Figure 1: Size, purity and oligomerization state of CoV-2 spike protein RBD domain assessed by SDS-PAGE, Western Blot using an anti-His antibody.
|Alternative names||SPIKE_SARS2 Spike glycoprotein|
|Protein class||Single span transmembrane protein|
|Organism||Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2)|
|Sequence||RBD domain (aa 319 – 537), K417N, E484K, N501Y, C-terminal His-tag|
|Affinity tag||C-terminal His-tag|
|Expression Host||Hek293 Expi cells|
|Size||225 amino acids (including His-tag) |
|Buffer composition||20 mM Hepes pH 7.5; 150 mM NaCl|
|Function||host cell surface receptor binding; fusion of virus membrane with host endosome membrane|
|Purity (SDS-PAGE)||>98% as determined by SDS-PAGE, see Fig. 1 A and B|
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