Active, purified GLP1R (Glucagon-like peptide 1 receptor)

Membrane proteins are the most pharmaceutically relevant protein class. At the same time, it is very difficult to obtain them in pure, active form. Cube Biotech's protein experts have worked hard to produce human GPCRs in sufficient quality that we can now offer to the community.

We offer active, purified GLP1R,  a human GPCR involved in insuline production and appetite regulation.

The protein is available off-the shelf, ready for ligand binding studies, crystallization, and other biochemical/biophysical experiments.


Please contact us for bulk inquiries, academic projects or collaboration ideas.


Active Membrane Proteins
Fig. 1: Size and purity of GLP1R assessed by SDS-PAGE and size exclusion chromatography. Note: GLP1R is always detected as a double band in SDS-PAGE.

Fig. 2: Surface plasmon resonance measurement of GLP1R-exendin interaction. Using a 1:1 binding model, the dissociation constant (Kd) value was determined to 6.11x10e-7 M.







GLP1R (Glucagon-like peptide 1 receptor)

Alternative names


UniProt number


Protein class

GPCR, class B


Human (Homo sapiens)


Full-length, wildtype sequence
N-terminal HA tag (underlined), 10x His-tag with spacer (red),
HRV 3C protease site (blue), spacer (gray), Rho1D4 tag (green)

Affinity tags

His / Rho1D4 (both C-terminal)
Size (excluding
additional elements)
489 (463) amino acids
56,170 (53,026) Da

Expression system

Sf9 (baculovirus)

Purified via

Protein-specific affinity matrix using immobilized agonist ligand, size exclusion chromatography


20 mM HEPES pH 7.5, 150 mM NaCl, 10% Glycerol, 0.02% Foscholine-12

Purity (SDS-PAGE)

>98% as determined by SDS-PAGE


Size exclusion chromatography


Ligand binding measured by SPR using the agonist ligand exendin-4 at 10°C. Using a 1:1 binding model, the dissociation constant (Kd) was determined to 6.11x10e-7 M, which is in accordance with published values.


Receptor for glucagon-like peptide 1. Expressed in pancreas, brain, heart, kidney and the GI tract. Involved in insuline secretion and appetite regulation.
Literature  references:
1. Hwang JI et al. Molecular evolution of GPCRs: GLP1/GLP1 receptors. J. Mol. Endocrinol. (2014) 52 (3) 15-27.
2. Sisley S. et al. Neuronal GLP1R mediates liraglutide's anorectic but not glucose-lowering effect. (2014) J. Clin. inv. 124(6)2456-2463.

Neuronal GLP1R mediates liraglutide's anorectic but not glucose-lowering effect.

Neuronal GLP1R mediates liraglutide's anorectic but not glucose-lowering effect.

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GLP1 Receptor

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Current Stock Level

GLP1R protein (10 ug)

Sales price: 998,00 €

Product details