SMALP 140
- Order number: 18220
Note: On October 1st 2021 this product was renamed from "SMALP 40005S" to "SMALP... more
Product information "SMALP 140"
Note: On October 1st 2021 this product was renamed from "SMALP 40005S" to "SMALP 140". Nothing else has changed. More on this renaming can be found here:
The synthethic polymer SMALP 140, among our other synthetic nanodisc products has been developed for for the solubilization & subsequent purification of membrane proteins from all kinds of cell membranes. SMALP products do this by using the phospholipids around the membrane proteins and form them into a disc-shaped structure in which the membrane proteins are centered.
SMALP 140 + its corresponding buffer are shipped in a lyophilized state, so they have to be dissolved in dH2O. Then the product is ready-to-use. SMALP 140 has a amber color in solution.
We recommend using affinity chromatography for the follow-up purification of the membrane protein of interest. The Rho1D4-tag has proven to be especially usefull for membrane protein purification. Cube Biotech offers the matching products for this purpose.
SMALP Screening: Different membrane protein usually perform different under different SMAs variants respectively. To ease the resulting screening process we compiled all of our SMAs into a convenient SMALP Screening Set.
Furthermore if you like to compare proteins's performance between DIBMA and SMA, we also offer our, that includes both our SMA and DIBMA products.
SMALP 140 + its corresponding buffer are shipped in a lyophilized state, so they have to be dissolved in dH2O. Then the product is ready-to-use. SMALP 140 has a amber color in solution.
We recommend using affinity chromatography for the follow-up purification of the membrane protein of interest. The Rho1D4-tag has proven to be especially usefull for membrane protein purification. Cube Biotech offers the matching products for this purpose.
SMALP Screening: Different membrane protein usually perform different under different SMAs variants respectively. To ease the resulting screening process we compiled all of our SMAs into a convenient SMALP Screening Set.
Furthermore if you like to compare proteins's performance between DIBMA and SMA, we also offer our, that includes both our SMA and DIBMA products.
Features
| State | Lyophilized Powder, to be solved with water |
| Polymer styrene-to-maleic anhydride ratio | 1.4:1 |
| Molecular weight | 5.000 |
| pH after solving | 7.5 |
| Solubility | 45% |
| Divalent cationic tolerance | < 5 mM |
| Color | Amber |
| Odor | Odorless |
| Freeze-thaw stable? | Yes |
| Storage | 4°C for long-term |
| Structure |  |
Figure 1: Western Blot of a purified membrane protein after stabilization through SMA. Reproduced with permission from Ms S. Nestorow, University of Birmingham.
Our protocol video that shows a full solubilization process using SMALP
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