ACE2 (Angiotensin-converting enzyme 2) is a carboxypeptidase that is located on the cells surface. It is most commonly known for it role as the entry point of the coronavirus (COVID-19 pandemic). We offer this protein full-length and its exo-domain as individual products.
The protein is available off-the shelf, ready for ligand binding studies, crystallization, and other biochemical/biophysical experiments.
Features
| Protein | ACE2 (Angiotensin-converting enzyme 2) |
| Alternative names | Angiotensin-converting enzyme homolog (ACEH); Angiotensin-converting enzyme-related carboxypeptidase (ACE-related carboxypeptidase); |
| UniProt number | Q9BYF1 |
| Protein classes | Single span transmembrane protein, Carboxypeptidase |
| Organism | Human (Homo sapiens) |
| Sequence | Ectodomain (AA 1 – 740), wildtype sequence and C-terminal 6 x His tag (red)
MSSSSWLLLS LVAVTAAQST IEEQAKTFLD KFNHEAEDLF YQSSLASWNY NTNITEENVQ NMNNAGDKWS AFLKEQSTLA QMYPLQEIQN LTVKLQLQAL QQNGSSVLSE DKSKRLNTIL NTMSTIYST GKVCNPDNPQ ECLLLEPGLN EIMANSLDYN ERLWAWESWR SEVGKQLRPL Y EEYVVLKN EMARANHYED YGDYWRGDYE VNGVDGYDYS RGQLIEDVEH TFEEIKPLYE HL HAYVRAK LMNAYPSYIS PIGCLPAHLL GDMWGRFWTNL YSLTVPFGQKP NIDVTDAMVD Q AWDAQRIF KEAEKFFVSV GLPNMTQGFWE NSMLTDPGNV QKAVCHPTAW DLGKGDFRIL M CTKVTMDD FLTAHHEMGH IQYDMAYAAQP FLLRNGANEG FHEAVGEIMS LSAATPKHLK S IGLLSPDF QEDNETEINF LLKQALTIVG TLPFTYMLE KWRWMVFKG EIPKDQWMKK WWEM KREIV GVVEPVPHD ETYCDPASLF HVSNDYSFIR YYTRTLYQFQ FQEALCQAA KHEGPLH KC DISNSTEAGQ KLFNMLRLGK SEPWTLALE NVVGAKNMNV RPLLNYFEPL FTWLKDQNK NSFVGWSTDW SPYADQSIKV RISLKSALGD KAYEWNDNEM YLFRSSVAYA MRQYFLKVKN QMILFGEED VRVANLKPRI SFNFFVTAPK NVSDIIPRTE VEKAIRMSRS RINDAFRLND NSLEFLGIQ PTLGPPNQPP VSHHHHHH
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| Affinity tags | C-terminal His-tag |
| Size (excluding additional elements) | 86,1 kDa |
| Expression system | Hek293 mammalia cells |
| Purified via | Ni-INDIGO Agarose and Size Exclusion Chromatograpy |
| Buffer | 20 mM Hepes, 100 mM NaCl; pH 7.4 |
| Purity (SDS-PAGE) | >95 % as determined by SDS-PAGE |
| Homogeneity | Size exclusion chromatography |
| Function | Host cell receptor for virus entry, Protease |
