Go to homepage
Global
USA
Cart
Buy also at
Buy also at

CD20 / MS4A1 - B-lymphocyte surface antigen CD20

Order number: 70723
CD20 / MS4A1 - B-lymphocyte surface antigen CD20
On Request
Ready to ship today
On Request

Description

We are excited to introduce our off-the-shelf, full-length, active, and native B-lymphocyte antigen CD20, commonly known as CD20. It is a surface protein on B cells that is essential for regulating B cell activation. The general function of CD20 is to maintain an optimal B cell immune response, particularly against T cell-independent antigens. CD20 is also associated with certain types of cancer, as it is a type of tumor marker. The amount of CD20 on blood cells may be higher in patients with leukaemia. CD20 is also targeted in B-cell disorders.

Our CD20 protein has been solubilized and stabilized using our NativeMP™ platform, ensuring it retains its native structure and full biological activity, making it ideal for various research applications.

Applications:

  • Screening/Validation
  • Biologics Development
  • Structure Determination
  • Small Molecule Drug Development

The protein delivered can be used for these specific applications. When ordering, please indicate which applications you intend to use the protein for in the contact form to ensure the best results.

For more details, explore our solubilization database.

copolymer vs detergents workflow
Fig. 1: Detergents create environments that lack native lipids, which can compromise protein function and stability. Copolymers, enable you to see and analyze these aspects within a native environment. They facilitate studying how your target interacts with its surrounding lipids, and allow assays to be conducted at body temperature.

Datasheets

Upon ordering, you will receive the corresponding datasheets and the Certificate of Analysis (CoA).
Feature
Alternative names MS4A1, B-lymphocyte surface antigen B1, Bp35 Leukocyte surface antigen, Leu-16 Membrane-spanning 4-domains subfamily A member 1, CD20
UniProt Number P11836
Protein class Receptor
Original host Homo sapiens
Expression system HEK293
Sequence, One-Letter Code MTTPRNSVNGTFPAEPMKGPIAMQSGPKPLFRRMSSLVGPTQSFFMRESKTLGAVQIMNGLFHIALGGLLMIPAGIYAPICVTVWYPLWGGIMYIISGSLLAATEKNSRKCLVKGKMIMNSLSLFAAISGMILSIMDILNIKISHFLKMESLNFIRAHTPYINIYNCEPANPSEKNSPSTQYCYSIQSLFLGILSVMLIFAFFQELVIAGIVENEWKRTCSRPKSNIVLLSAEEKKEQTIEIKEEVVGLTETSSQPKNEEDIEIIPIQEEEEEETETNFPEPPQDQESSPIENDSSPGSSGTETSQVAPA
Affinity tags Rho1D4-tag (C-terminal)
Size (excluding additional elements) 335 amino acids, 38 kDa (Homotetramer)
Concentration 0.4 - 0.7 mg/ml
Purity >90%, determined via SDS-PAGE
Purification process 2-step purification
Shipping Shipment is carried out on dry-ice for temperature stability to ensure the integrity of the product.
Function B-lymphocyte antigen CD20 is a surface protein on B cells that is essential for regulating B cell activation. The general function of CD20 is to maintain an optimal B cell immune response, particularly against T cell-independent antigens. CD20 is also associated with certain types of cancer, as it is a type of tumor marker. The amount of CD20 on blood cells may be higher in patients with leukaemia. CD20 is also targeted in B-cell disorders.
PubMed ID 2448768, 2456210, 2466899, 3925015, 2472394, 7684739, 12920111, 3260267

Lab Results

CD20 Eluate +DLS
Figure 2: Exemplary in-house SDS-Page and DLS data of CD20 NativeMP™ copolymer screens. More in-depth data sets can be accessed upon project initiation.