Structure Gallery
Cube Biotech and CryoEM
Cryo-electron microscopy (cryoEM) has become a key tool in drug discovery and structure-based drug design, offering critical insights into membrane protein targets.
Our NativeMP™ platform has been instrumental in determining numerous high-resolution structures of membrane proteins with cryoEM. By maintaining the native lipid environment, we ensure proteins retain their full functionality.
The images below showcase several membrane protein structures stabilized by our NativeMP™ copolymers.
See our full publication list here.
ecYnaI
Copolymer: SMA
Resolution: 2.4 Å
Visible lipids: -
Reference: Catalano et al (2021) Membranes 11: 849
Uniprot: P0AEB5
ggASC1
Copolymer: SMA
Resolution: 2.8 – 3.7 Å
Visible lipids: Yes
Reference: Yoder and Gouaux (2020) eLife 9:e56527
Uniprot: Q1XA76
PDB/EMDB: 6VTK/21380
ecMscS
Copolymer: SMA/UltrasoluteTM Amphipol 18/Glyco-DIBMA
Resolution: 2.9 – 3.0 Å
Visible lipids: Yes, in DIBMA
Reference: Moller et al (2024) Biorxiv: 10.1101/ 2024.01.22.576751
drGlyR
Copolymer: SMA
Resolution: 2.8 – 4 Å
Visible lipids: No
Reference: Yu et al. (2021) Cell 184:957-68
PDB/EMDB: EMD-20389
ecYnaI
Copolymer: DIBMA
Resolution: 3.0 Å
Visible lipids: Yes
Reference: Flegler et al. (2020) PNAS 117:28754-62
Uniprot: P0AEB5
PDB/EMDB: 6ZYD/11557
ecArcB
Copolymer: SMA
Resolution: 3.2 Å
Visible lipids: Yes
Reference: Qiu et al. (2018) PNAS 115:12985-90
Uniprot: P31224
PDB/EMDB: EMD-7074
ecAcrB
Copolymer: UltrasoluteTM Amphipol 18
Resolution: 3.2 Å
Visible lipids: No
Reference: Higgins et al. (2021) Commun. Biol. 4:1-9
Uniprot: P31224
PDB/EMDB: 7B5P/12043
ecBAM/EspP
Copolymer: SMA
Resolution: 3.6 – 4.8 Å
Visible lipids: Yes
Reference: Doyle et al (2022) Cell. 185:1143-56
fjACIII
Copolymer: SMA
Resolution: 3.4 Å
Visible lipids: Lipid anchor
Reference: Sun et al (2018) Nature 557: 123-6
fjACIII
Copolymer: SMA
Resolution: 3.7 Å
Visible lipids: No
Reference: Tascón et al (2020) Nat. Commun. 11: 626
rsCyt bc1
Copolymer: SMA
Resolution: 2.9 Å
Visible lipids: Yes
Reference: Swainsbury et al (2023) PNAS 12: e2217922120
Uniprot: Q3IY09/ Q3IY10/ Q3IY11/ Q3J2Z2
PDB/EMDB: 8ASI/15616
hsTRPM4
Copolymer: SMA
Resolution: 3.6 – 4.5 Å
Visible lipids: Yes
Reference: Ekundayo et al (2024) Biorxiv: 2024.01.22.576650
pLIC
Copolymer: SMA
Resolution: 3.7 Å
Visible lipids: No
Reference: Dalal et al (2024) Nat. Commun 15: 25
