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CD68 / Gp110 - Macrosialin

Order number: 70732
CD68 / Gp110 - Macrosialin
On Request
Ready to ship today
On Request

Description

We are excited to introduce our off-the-shelf, full-length, active, and native Macrosialin, commonly known as CD68. This protein is involved in phagocytotic activities, modulation of intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. It plays a critical role in the immune response and is also important in mediating and regulating inflammatory responses. This essential protein is used to identify immune cells in tissues.

Our CD68 protein has been solubilized and stabilized using our NativeMP™ platform, ensuring it retains its native structure and full biological activity, making it ideal for various research applications.
  Applications:
  • Screening/Validation
  • Biologics Development
  • Structure Determination
  • Small Molecule Drug Development

The protein delivered can be used for these specific applications. When ordering, please indicate which applications you intend to use the protein for in the contact form to ensure the best results.

For more details, explore our solubilization database.

copolymer vs detergents workflow
Fig. 1: Detergents create environments that lack native lipids, which can compromise protein function and stability. Copolymers, enable you to see and analyze these aspects within a native environment. They facilitate studying how your target interacts with its surrounding lipids, and allow assays to be conducted at body temperature.

Datasheets

Upon ordering, you will receive the corresponding datasheets and the Certificate of Analysis (CoA).
Feature
Alternative names CD68, Gp110
UniProt Number P34810
Protein class Receptor
Original host Homo sapiens
Expression system HEK293
Sequence, One-Letter Code MRLAVLFSGALLGLLAAQGTGNDCPHKKSATLLPSFTVTPTVTESTGTTSHRTTKSHKTTTHRTTTTGTTSHGPTTATHNPTTTSHGNVTVHPTSNSTATSQGPSTATHSPATTSHGNATVHPTSNSTATSPGFTSSAHPEPPPPSPSPSPTSKETIGDYTWTNGSQPCVHLQAQIQIRVMYTTQGGGEAWGISVLNPNKTKVQGSCEGAHPHLLLSFPYGHLSFGFMQDLQQKVVYLSYMAVEYNVSFPHAAQWTFSAQNASLRDLQAPLGQSFSCSNSSIILSPAVHLDLLSLRLQAAQLPHTGVFGQSFSCPSDRSILLPLIIGLILLGLLALVLIAFCIIRRRPSAYQALGSSGTETSQVAPA
Affinity tags Rho1D4-tag (C-terminal)
Size (excluding additional elements) 354 amino acids, 37 kDa
Concentration 0.4 - 0.7 mg/ml
Purity >90%, determined via SDS-PAGE
Purification process 2-step purification
Shipping Shipment is carried out on dry-ice for temperature stability to ensure the integrity of the product.
Function Macrosialin is involved in phagocytotic activities, modulation of intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. It plays a critical role in the immune response and is also important in mediating and regulating inflammatory responses. This essential protein is used to identify immune cells in tissues.
PubMed ID 7680921, 9790779, 15194571, 15647451, 16263699, 18405323, 19159218, 25944712, 8692836