TNF1A / TNFR1 - Tumor necrosis factor receptor superfamily member 1A

Order number: 70360

€17,800.00*

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Description

We are excited to introduce our off-the-shelf, full-length, active, and native Tumour necrosis factor alpha. TNF1A belongs to the TNF superfamily and is a central mediator of immune regulation and inflammation, as well as other biological processes including apoptosis, lipid metabolism, cell proliferation and differentiation. TNF1A has been implicated in several health conditions including cancer, tuberculosis, insulin resistance and autoimmune diseases.

Our TNF1A protein has been solubilized and stabilized using our NativeMP™ platform, ensuring it retains its native structure and full biological activity, making it ideal for various research applications.

Applications:

Screening/Validation
Biologics Development
Structure Determination
Small Molecule Drug Development

The protein delivered can be used for these specific applications. When ordering, please indicate which applications you intend to use the protein for in the contact form to ensure the best results.

For more details, explore our solubilization database.

copolymer vs detergents workflow — **Fig. 1:** Detergents create environments that lack native lipids, which can compromise protein function and stability. Copolymers, enable you to see and analyze these aspects within a native environment. They facilitate studying how your target interacts with its surrounding lipids, and allow assays to be conducted at body temperature.

Datasheets

Upon ordering, you will receive the corresponding datasheets and the Certificate of Analysis (CoA).

Feature
Alternative names	TNF1A, TNFRSF1A, TNFAR, TNFR1, Tumor necrosis factor receptor 1 (TNF-R1), Tumor necrosis factor receptor type I, TNF-RI, p55, p60
UniProt Number	P19438
Protein class	Receptor
Original host	Homo sapiens
Expression system	HEK293
Sequence, One-Letter Code	MGLSTVPDLLLPLVLLELLVGIYPSGVIGLVPHLGDREKRDSVCPQGKYIHPQNNSICCTKCHKGTYLYNDCPGPGQDTDCRECESGSFTASENHLRHCLSCSKCRKEMGQVEISSCTVDRDTVCGCRKNQYRHYWSENLFQCFNCSLCLNGTVHLSCQEKQNTVCTCHAGFFLRENECVSCSNCKKSLECTKLCLPQIENVKGTEDSGTTVLLPLVIFFGLCLLSLLFIGLMYRYQRWKSKLYSIVCGKSTPEKEGELEGTTTKPLAPNPSFSPTPGFTPTLGFSPVPSSTFTSSSTYTPGDCPNFAAPRREVAPPYQGADPILATALASDPIPNPLQKWEDSAHKPQSLDTDDPATLYAVVENVPPLRWKEFVRRLGLSDHEIDRLELQNGRCLREAQYSMLATWRRRTPRREATLELLGRVLRDMDLLGCLEDIEEALCGPAALPPAPSLLRGSSGTETSQVAPA
Affinity tags	Rho1D4-tag (C-terminal)
Size (excluding additional elements)	455 amino acids, 50 kDa (forms Homotrimers)
Concentration	0.4 - 0.7 mg/ml
Purity	>90%, determined via SDS-PAGE
Purification process	2-step purification
Shipping	Shipment is carried out on dry-ice for temperature stability to ensure the integrity of the product.
Function	Tumour necrosis factor alpha belongs to the TNF superfamily and is a central mediator of immune regulation and inflammation, as well as other biological processes including apoptosis, lipid metabolism, cell proliferation and differentiation. TNF1A has been implicated in several health conditions including cancer, tuberculosis, insulin resistance and autoimmune diseases.
PubMed ID	2158862, 2158863, 1702293, 1698610, 2170974, 1315717, 19906316