TNF1B / TNFR2 - Tumor necrosis factor receptor superfamily member 1B

Order number: 70350

€17,800.00*

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Amount

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Description

We are excited to introduce our off-the-shelf, full-length, active, and native Tumor necrosis factor receptor superfamily member 1B, commonly known as TNF1B. This protein, like TNF1A, is a member of the TNF supergroup and plays a key role in immune regulation and inflammatory responses. It regulates TNF1A by blocking TNF1A-induced apoptosis, thereby antagonising its biological function. In general, TNF1B is considered a target for anti-inflammatory therapies.

Our TNF1B protein has been solubilized and stabilized using our NativeMP™ platform, ensuring it retains its native structure and full biological activity, making it ideal for various research applications.

Applications:

Screening/Validation
Biologics Development
Structure Determination
Small Molecule Drug Development

The protein delivered can be used for these specific applications. When ordering, please indicate which applications you intend to use the protein for in the contact form to ensure the best results.

For more details, explore our solubilization database.

copolymer vs detergents workflow — **Fig. 1:** Detergents create environments that lack native lipids, which can compromise protein function and stability. Copolymers, enable you to see and analyze these aspects within a native environment. They facilitate studying how your target interacts with its surrounding lipids, and allow assays to be conducted at body temperature.

Datasheets

Upon ordering, you will receive the corresponding datasheets and the Certificate of Analysis (CoA).

Feature
Alternative names	TNF1B, Tumor necrosis factor receptor 2 (TNF-R2), Tumor necrosis factor receptor type II, TNFRSF1B, TNFBR, TNFR2, p75, p80
UniProt Number	P20333
Protein class	Receptor
Original host	Homo sapiens
Expression system	HEK293
Sequence, One-Letter Code	MAPVAVWAALAVGLELWAAAHALPAQVAFTPYAPEPGSTCRLREYYDQTAQMCCSKCSPGQHAKVFCTKTSDTVCDSCEDSTYTQLWNWVPECLSCGSRCSSDQVETQACTREQNRICTCRPGWYCALSKQEGCRLCAPLRKCRPGFGVARPGTETSDVVCKPCAPGTFSNTTSSTDICRPHQICNVVAIPGNASMDAVCTSTSPTRSMAPGAVHLPQPVSTRSQHTQPTPEPSTAPSTSFLLPMGPSPPAEGSTGDFALPVGLIVGVTALGLLIIGVVNCVIMTQVKKKPLCLQREAKVPHLPADKARGTQGPEQQHLLITAPSSSSSSLESSASALDRRAPTRNQPQAPGVEASGAGEARASTGSSDSSPGGHGTQVNVTCIVNVCSSSDHSSQCSSQASSTMGDTDSSPSESPKDEQVPFSKEECAFRSQLETPETLLGSTEEKPLPLGVPDAGMKPSGSSGTETSQVAPA
Affinity tags	Rho1D4-tag (C-terminal)
Size (excluding additional elements)	461 amino acids, 48 kDa (forms Homotrimers)
Concentration	0.4 - 0.7 mg/ml
Purity	>90%, determined via SDS-PAGE
Purification process	2-step purification
Shipping	Shipment is carried out on dry-ice for temperature stability to ensure the integrity of the product.
Function	Tumor necrosis factor receptor superfamily member 1B, like TNF1A,is a member of the TNF supergroup and plays a key role in immune regulation and inflammatory responses. It regulates TNF1A by blocking TNF1A-induced apoptosis, thereby antagonising its biological function. In general, TNF1B is considered a target for anti-inflammatory therapies.
PubMed ID	2172983, 2160731, 8661109, 14688072, 2173696, 8015639, 2153136