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Integrin alpha-V (ITGAV) & Integrin beta-3 (ITGB3)

Order number: 70161
Integrin alpha-V (ITGAV) & Integrin beta-3 (ITGB3)

€12,800.00*

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Description

Introducing our off-the-shelf, full-length, active, and native co-expression of the Integrins Beta-3 & Alpha-V, also known as ITGB3/ITGAV. These essential membrane proteins play a critical role in the development and progression of various diseases. Their role in angiogenesis, in cancer and other diseases, is linked to the blood supply for problematic overgrowths.

Our ITGB3/ITGAV proteins are solubilized and stabilized using our innovative NativeMP™ platform. This ensures that the proteins retain their native structure and full biological activity, making them ideal for research applications in immunology, angiogenesis, and drug discovery.

Applications:

  • Screening/Validation
  • Biologics Development
  • Structure Determination
  • Small Molecule Drug Development

The proteins delivered can be used for these specific applications. When ordering, please indicate which applications you intend to use the proteins for in the contact form to ensure the best results.

For more details, explore our solubilization database.

copolymer vs detergents workflow
Fig. 1: Detergents create environments that lack native lipids, which can compromise protein function and stability. Copolymers, enable you to see and analyze these aspects within a native environment. They facilitate studying how your target interacts with its surrounding lipids, and allow assays to be conducted at body temperature.

Datasheets

Upon ordering, you will receive the corresponding datasheets and the Certificate of Analysis (CoA).
Feature
Alternative names ITGAV ITGAV, CD51, MSK8, VNRA, VTNR
Alternative names ITGB3 ITGB3, CD61, GP3A
UniProt Number P06756 (ITGAV), P05106 (ITGB3)
Protein class Integrin
Original host Homo sapiens
Expression system HEK293, Co-expression
Sequence, ITGAV-StrepII MAFPPRRRLRLGPRGLPLLLSGLLLPLCRAFNLDVDSPAEYSGPEGSYFGFAVDFFVPSASSRMFLLVGAPKANTTQPGIVEGGQVLKCDWSSTRRCQPIEFDATGNRDYAKDDPLEFKSHQWFGASVRSKQDKILACAPLYHWRTEMKQEREPVGTCFLQDGTKTVEYAPCRSQDIDADGQGFCQGGFSIDFTKADRVLLGGPGSFYWQGQLISDQVAEIVSKYDPNVYSIKYNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIDDFVSGVPRAARTLGMVYIYDGKNMSSLYNFTGEQMAAYFGFSVAATDINGDDYADVFIGAPLFMDRGSDGKLQEVGQVSVSLQRASGDFQTTKLNGFEVFARFGSAIAPLGDLDQDGFNDIAIAAPYGGEDKKGIVYIFNGRSTGLNAVPSQILEGQWAARSMPPSFGYSMKGATDIDKNGYPDLIVGAFGVDRAILYRARPVITVNAGLEVYPSILNQDNKTCSLPGTALKVSCFNVRFCLKADGKGVLPRKLNFQVELLLDKLKQKGAIRRALFLYSRSPSHSKNMTISRGGLMQCEELIAYLRDESEFRDKLTPITIFMEYRLDYRTAADTTGLQPILNQFTPANISRQAHILLDCGEDNVCKPKLEVSVDSDQKKIYIGDDNPLTLIVKAQNQGEGAYEAELIVSIPLQADFIGVVRNNEALARLSCAFKTENQTRQVVCDLGNPMKAGTQLLAGLRFSVHQQSEMDTSVKFDLQIQSSNLFDKVSPVVSHKVDLAVLAAVEIRGVSSPDHVFLPIPNWEHKENPETEEDVGPVVQHIYELRNNGPSSFSKAMLHLQWPYKYNNNTLLYILHYDIDGPMNCTSDMEINPLRIKISSLQTTEKNDTVAGQGERDHLITKRDLALSEGDIHTLGCGVAQCLKIVCQVGRLDRGKSAILYVKSLLWTETFMNKENQNHSYSLKSSASFNVIEFPYKNLPIEDITNSTLVTTNVTWGIQPAPMPVPVWVIILAVLAGLLLLAVLVFVMYRMGFFKRVRPPQEEQEREQLQPHENGEGNSETGGASWSHPQFEK
Sequence, ITGB3-Rho1D4MRARPRPRPLWATVLALGALAGVGVGGPNICTTRGVSSCQQCLAVSPMCAWCSDEALPLGSPRCDLKENLLKDNCAPESIEFPVSEARVLEDRPLSDKGSGDSSQVTQVSPQRIALRLRPDDSKNFSIQVRQVEDYPVDIYYLMDLSYSMKDDLWSIQNLGTKLATQMRKLTSNLRIGFGAFVDKPVSPYMYISPPEALENPCYDMKTTCLPMFGYKHVLTLTDQVTRFNEEVKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRNDASHLLVFTTDAKTHIALDGRLAGIVQPNDGQCHVGSDNHYSASTTMDYPSLGLMTEKLSQKNINLIFAVTENVVNLYQNYSELIPGTTVGVLSMDSSNVLQLIVDAYGKIRSKVELEVRDLPEELSLSFNATCLNNEVIPGLKSCMGLKIGDTVSFSIEAKVRGCPQEKEKSFTIKPVGFKDSLIVQVTFDCDCACQAQAEPNSHRCNNGNGTFECGVCRCGPGWLGSQCECSEEDYRPSQQDECSPREGQPVCSQRGECLCGQCVCHSSDFGKITGKYCECDDFSCVRYKGEMCSGHGQCSCGDCLCDSDWTGYYCNCTTRTDTCMSSNGLLCSGRGKCECGSCVCIQPGSYGDTCEKCPTCPDACTFKKECVECKKFDRGALHDENTCNRYCRDEIESVKELKDTGKDAVNCTYKNEDDCVVRFQYYEDSSGKSILYVVEEPECPKGPDILVVLLSVMGAILLIGLAALLIWKLLITIHDRKEFAKFEEERARAKWDTANNPLYKEATSTFTNITYRGTGSSGTETSQVAPA
Affinity tags ITGAV-StrepII (C-terminal); ITGB3-Rho1D4-tag (C-terminal)
Size ITGAV 1060 amino acids, 117 kDa
Size ITGB3 801 amino acids, 88 kDa
Concentration 0.4 - 0.7 mg/ml
Purity >90%, determined via SDS-PAGE
Purification process 3-step purification
Shipping Shipment is carried out on dry-ice for temperature stability to ensure the integrity of the product.
Function The heterodimer of ITGB3 and ITGAV, forming the αVß3 integrin, is associated with various diseases, including cancer, cardiovascular conditions (like atherosclerosis and restenosis), bone diseases (such as osteoporosis), ocular disorders (age-related macular degeneration and diabetic retinopathy), fibrosis, and thrombosis-related bleeding disorders like Glanzmann thrombasthenia. Additionally, it plays a role in autoimmune diseases like multiple sclerosis and rheumatoid arthritis.
PubMed ID 34359854, 26126915, 27108184, 34359854, 29957044, 38009896, 23821196, 33827580, 27422811, 37681860

Lab Results

ITGB3/ITGAV Eluate +DLS
Fig. 2: Exemplary in-house SDS-Page and DLS data of ITGB3/ITGAV NativeMP™ copolymer screens. More in-depth data sets can be accessed upon project initiation