ADRB2 / B2AR - Beta-2 adrenergic receptor

Order number: 70430

€12,800.00*

Ready to ship today

Amount (µg)

Quantity

Description

We are excited to introduce our off-the-shelf, full-length, active, and native Beta-2 adrenergic receptor, commonly known as ADRB2. It is part of a receptor channel complex,consisting of a G protein, an adenylyl cyclase, a cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. ADRB2 is crucial for smooth muscle relaxation and it is also targeted for asthma and COPD treatment.

Our ADRB1 protein has been solubilized and stabilized using our NativeMP™ platform, ensuring it retains its native structure and full biological activity, making it ideal for various research applications.

Applications:

Screening/Validation
Biologics Development
Structure Determination
Small Molecule Drug Development

The protein delivered can be used for these specific applications. When ordering, please indicate which applications you intend to use the protein for in the contact form to ensure the best results.

For more details, explore our solubilization database.

copolymer vs detergents workflow — **Fig. 1:** Detergents create environments that lack native lipids, which can compromise protein function and stability. Copolymers, enable you to see and analyze these aspects within a native environment. They facilitate studying how your target interacts with its surrounding lipids, and allow assays to be conducted at body temperature.

Datasheets

Upon ordering, you will receive the corresponding datasheets and the Certificate of Analysis (CoA).

Feature
Alternative names	ADRB2, ADRB2R, B2AR
UniProt Number	P07550
Protein class	GPCR
Subclass	Class A (Aminergic)
Original host	Homo sapiens
Expression system	Trichoplusia ni
Sequence, One-Letter Code	MKTIIALSYIFCLVFADYKDDDDKLEVLFQGPGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLLGSSGTETSQVAPA
Affinity tags	HA signal peptide, FLAG-tag, HRV cleavage site (N-terminal); Rho1D4-tag (C-terminal)
Size (excluding additional elements)	413 amino acids, 46 kDa
Concentration	0.4 - 0.7 mg/ml
Purity	>90%, determined via SDS-PAGE
Purification process	2-step purification
Shipping	Shipment is carried out on dry-ice for temperature stability to ensure the integrity of the product.
Function	Beta-2 adrenergic receptor, commonly known as ADRB2, is part of a receptor channel complex comprised of a G protein, an adenylyl cyclase, a cAMP-dependent kinase and a counterbalancing phosphatase, PP2A. ADRB2 is invovled in the mediation of physiological responses including the smooth muscle relaxation and it is also targeted for treatment of asthma and COPD.
PubMed ID	32755608, 17199132, 31090079

Lab Results

ADRB2 Eluate +DLS — **Figure 2:** Exemplary in-house SDS-Page and DLS data of ADRB2 NativeMP™ copolymer screens. More in-depth data sets can be accessed upon project initiation.