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AQP1 / AQP-1 - Aquaporin-1

Order number: 70873
AQP1 / AQP-1 - Aquaporin-1
On Request
Ready to ship today
On Request

Description

We are excited to introduce our off-the-shelf, full-length, active, and native Aquaporin-1, commonly known as AQP1. It is a protein involved in water homeostasis in several tissues by forming a water channel that allows passive transport of water along the osmotic gradient. It is implicated in the inter- and intracellular transport of water and is mainly expressed in the kidney. AQP1 may be associated with various health conditions, such as ocular fluid movement, but it could also be a prognostic marker for various types of cancer, as AQP1 has been shown to regulate tumour cell migration, cell-cell adhesion and angiogenesis, among other things, and is thus invovled in cancer progression.

Our AQP1 protein has been solubilized and stabilized using our NativeMP™ platform, ensuring it retains its native structure and full biological activity, making it ideal for various research applications.

Applications:

  • Screening/Validation
  • Biologics Development
  • Structure Determination
  • Small Molecule Drug Development

The protein delivered can be used for these specific applications. When ordering, please indicate which applications you intend to use the protein for in the contact form to ensure the best results.

For more details, explore our solubilization database.

copolymer vs detergents workflow
Fig. 1: Detergents create environments that lack native lipids, which can compromise protein function and stability. Copolymers, enable you to see and analyze these aspects within a native environment. They facilitate studying how your target interacts with its surrounding lipids, and allow assays to be conducted at body temperature.

Datasheets

Upon ordering, you will receive the corresponding datasheets and the Certificate of Analysis (CoA).
Feature
Alternative names AQP1, Aquaporin-CHIP, Channel-like integral membrane protein of 28 kDa, Urine water channel
UniProt Number P29972
Protein class Aquaporin
Original host Homo sapiens
Expression system HEK293
Sequence, One-Letter Code MASEFKKKLFWRAVVAEFLATTLFVFISIGSALGFKYPVGNNQTAVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQISIFRALMYIIAQCVGAIVATAILSGITSSLTGNSLGRNDLADGVNSGQGLGIEIIGTLQLVLCVLATTDRRRRDLGGSAPLAIGLSVALGHLLAIDYTGCGINPARSFGSAVITHNFSNHWIFWVGPFIGGALAVLIYDFILAPRSSDLTDRVKVWTSGQVEEYDLDADDINSRVEMKPKGSSGTETSQVAPA
Affinity tags Rho1D4-tag (C-terminal)
Size (excluding additional elements) 269 amino acids, 29 kDa (Homotetramer)
Concentration 0.4 - 0.7 mg/ml
Purity >90%, determined via SDS-PAGE
Purification process 2-step purification
Shipping Shipment is carried out on dry-ice for temperature stability to ensure the integrity of the product.
Function Aquaporin-1 is a protein involved in water homeostasis in several tissues by forming a water channel that allows passive transport of water along the osmotic gradient. It is implicated in the inter- and intracellular transport of water and is mainly expressed in the kidney. AQP1 may be associated with various health conditions, such as ocular fluid movement, but it could also be a prognostic marker for various types of cancer, as AQP1 has been shown to regulate tumour cell migration, cell-cell adhesion and angiogenesis, among other things, and is thus invovled in cancer progression.
PubMed ID 1722319, 8340403, 8703970, 7517253, 19054851