Go to homepage
Global
USA
Cart
Buy also at
Buy also at

AQP2 / AQP-2 - Aquaporin-2

Order number: 70882
AQP2 / AQP-2 - Aquaporin-2
On Request
Ready to ship today
On Request

Description

We are excited to introduce our off-the-shelf, full-length, active, and native Aquaporin-2, commonly known as AQP2. This aquaporin is a transmembrane protein that plays a crucial role in renal homeostasis, and the expression of Aqp2 in the kidney depends on the secretion of the hormone ADH, particularly for water retention. Mutations in AQP2 have been associated with water balance disorders such as congenital nephrogenic diabetes insipidus.

Our AQP2 protein has been solubilized and stabilized using our NativeMP™ platform, ensuring it retains its native structure and full biological activity, making it ideal for various research applications.

Applications:

  • Screening/Validation
  • Biologics Development
  • Structure Determination
  • Small Molecule Drug Development

The protein delivered can be used for these specific applications. When ordering, please indicate which applications you intend to use the protein for in the contact form to ensure the best results.

For more details, explore our solubilization database.

copolymer vs detergents workflow
Fig. 1: Detergents create environments that lack native lipids, which can compromise protein function and stability. Copolymers, enable you to see and analyze these aspects within a native environment. They facilitate studying how your target interacts with its surrounding lipids, and allow assays to be conducted at body temperature.

Datasheets

Upon ordering, you will receive the corresponding datasheets and the Certificate of Analysis (CoA).
Feature
Alternative names AQP2 , AQP-2, ADH water channel, Aquaporin-CD, AQP-CD, Collecting duct water channel protein, WCH-CD
UniProt Number P41181
Protein class Aquaporin
Original host Homo sapiens
Expression system HEK293
Sequence, One-Letter Code MWELRSIAFSRAVFAEFLATLLFVFFGLGSALNWPQALPSVLQIAMAFGLGIGTLVQALGHISGAHINPAVTVACLVGCHVSVLRAAFYVAAQLLGAVAGAALLHEITPADIRGDLAVNALSNSTTAGQAVTVELFLTLQLVLCIFASTDERRGENPGTPALSIGFSVALGHLLGIHYTGCSMNPARSLAPAVVTGKFDDHWVFWIGPLVGAILGSLLYNYVLFPPAKSLSERLAVLKGLEPDTDWEEREVRRRQSVELHSPQSLPRGTKAGSSGTETSQVAPA
Affinity tags Rho1D4-tag (C-terminal)
Size (excluding additional elements) 271 amino acids, 29 kDa (Homotetramer)
Concentration 0.4 - 0.7 mg/ml
Purity >90%, determined via SDS-PAGE
Purification process 2-step purification
Shipping Shipment is carried out on dry-ice for temperature stability to ensure the integrity of the product.
Function Aquaporin-2, commonly known as AQP2. This aquaporin is a transmembrane protein that plays a crucial role in renal homeostasis, and the expression of Aqp2 in the kidney depends on the secretion of the hormone ADH, particularly for water retention. Mutations in AQP2 have been associated with water balance disorders such as congenital nephrogenic diabetes insipidus.
PubMed ID 8140421, 7522228, 7524315, 7510718, 11929850, 8584435, 12194985