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AQP3 / AQP-3 - Aquaglyceroporin-3

Order number: 70893
AQP3 / AQP-3 - Aquaglyceroporin-3
On Request
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On Request

Description

We are excited to introduce our off-the-shelf, full-length, active, and native Aquaporin-3, commonly known as AQP3. This protein is a homotetrameric channel in which each monomer independently mediates the transport of glycerol and water along its osmotic gradient. In humans, it functions mainly in the kidney, where it plays a crucial role in the reabsorption of water, leading to the maintenance of fluid balance, and in the skin, where it is involved in the transport of glycerol, which is relevant for elasticity and hydration.

Our AQP3 protein has been solubilized and stabilized using our NativeMP™ platform, ensuring it retains its native structure and full biological activity, making it ideal for various research applications.

Applications:

  • Screening/Validation
  • Biologics Development
  • Structure Determination
  • Small Molecule Drug Development

The protein delivered can be used for these specific applications. When ordering, please indicate which applications you intend to use the protein for in the contact form to ensure the best results.

For more details, explore our solubilization database.

copolymer vs detergents workflow
Fig. 1: Detergents create environments that lack native lipids, which can compromise protein function and stability. Copolymers, enable you to see and analyze these aspects within a native environment. They facilitate studying how your target interacts with its surrounding lipids, and allow assays to be conducted at body temperature.

Datasheets

Upon ordering, you will receive the corresponding datasheets and the Certificate of Analysis (CoA).
Feature
Alternative names AQP3, Aquaglyceroporin-3, AQP-3
UniProt Number Q92482
Protein class Aquaporin
Original host Homo sapiens
Expression system HEK293
Sequence, One-Letter Code MGRQKELVSRCGEMLHIRYRLLRQALAECLGTLILVMFGCGSVAQVVLSRGTHGGFLTINLAFGFAVTLGILIAGQVSGAHLNPAVTFAMCFLAREPWIKLPIYTLAQTLGAFLGAGIVFGLYYDAIWHFADNQLFVSGPNGTAGIFATYPSGHLDMINGFFDQFIGTASLIVCVLAIVDPYNNPVPRGLEAFTVGLVVLVIGTSMGFNSGYAVNPARDFGPRLFTALAGWGSAVFTTGQHWWWVPIVSPLLGSIAGVFVYQLMIGCHLEQPPPSNEEENVKLAHVKHKEQIGSSGTETSQVAPA
Affinity tags Rho1D4-tag (C-terminal)
Size (excluding additional elements) 292 amino acids, 32 kDa (forms Homotetramers)
Concentration 0.4 - 0.7 mg/ml
Purity >90%, determined via SDS-PAGE
Purification process 2-step purification
Shipping Shipment is carried out on dry-ice for temperature stability to ensure the integrity of the product.
Function Aquaporin-3 is a homotetrameric channel in which each monomer independently mediates the transport of glycerol and water along its osmotic gradient. In humans, it functions mainly in the kidney, where it plays a crucial role in the reabsorption of water, leading to the maintenance of fluid balance, and in the skin, where it is involved in the transport of glycerol, which is relevant for elasticity and hydration.
PubMed ID 7558005, 12239222, 11751877, 18495115, 20724658