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AQP4 / AQP-4 - Aquaporin-4

Order number: 70902
AQP4 / AQP-4 - Aquaporin-4
On Request
Ready to ship today
On Request

Description

We are excited to introduce our off-the-shelf, full-length, active, and native Aquaporin-4, commonly known as AQP4. This essential protein forms a water-specific channel to regulate brain water homeostasis. In general, it is essential for maintaining water exchange across the blood-brain interface. It has been linked to several health conditions such as neuromyelitis optica and cerebral oedema, and may also be associated with Alzheimer's disease.

Our AQP4 protein has been solubilized and stabilized using our NativeMP™ platform, ensuring it retains its native structure and full biological activity, making it ideal for various research applications.

Applications:

  • Screening/Validation
  • Biologics Development
  • Structure Determination
  • Small Molecule Drug Development

The protein delivered can be used for these specific applications. When ordering, please indicate which applications you intend to use the protein for in the contact form to ensure the best results.

For more details, explore our solubilization database.

copolymer vs detergents workflow
Fig. 1: Detergents create environments that lack native lipids, which can compromise protein function and stability. Copolymers, enable you to see and analyze these aspects within a native environment. They facilitate studying how your target interacts with its surrounding lipids, and allow assays to be conducted at body temperature.

Datasheets

Upon ordering, you will receive the corresponding datasheets and the Certificate of Analysis (CoA).
Feature
Alternative names AQP4, AQP-4, Mercurial-insensitive water channel, MIWC , WCH4
UniProt Number P55087
Protein class Aquaporin
Original host Homo sapiens
Expression system HEK293
Sequence, One-Letter Code MSDRPTARRWGKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWGGTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVHVIDVDRGEEKKGKDQSGEVLSSVGSSGTETSQVAPA
Affinity tags Rho1D4-tag (C-terminal)
Size (excluding additional elements) 323 amino acids, 35 kDa (forms Homotetramers)
Concentration 0.4 - 0.7 mg/ml
Purity >90%, determined via SDS-PAGE
Purification process 2-step purification
Shipping Shipment is carried out on dry-ice for temperature stability to ensure the integrity of the product.
Function Aquaporin-4, commonly known as AQP4. This essential protein forms a water-specific channel to regulate brain water homeostasis. In general, it is essential for maintaining water exchange across the blood-brain interface. It has been linked to several health conditions such as neuromyelitis optica and cerebral oedema, and may also be associated with Alzheimer's disease.
PubMed ID 8601457, 8855281, 16177791, 37143309, 9829975, 38802114, 38383779