Claudin-1 (CLDN1, CLD1, SEMP1, UNQ481/PRO944)
Order number: 70041
Description
We are excited to offer our off-the-shelf, full-length, active, and native Claudin-1 protein, also known as CLDN1, CLD1, SEMP1, and UNQ481/PRO944. Claudin-1 is a key component of tight junctions, which regulate the permeability of epithelial and endothelial cell layers. It plays a crucial role in maintaining cell polarity and barrier function, making it an important target in research areas such as cancer, viral infections, and tissue integrity.
Our Claudin-1 protein is solubilized and stabilized using Cube Biotech's NativeMP™ platform, ensuring it retains its native structure and full biological activity, making it ideal for a variety of research applications.
Applications:
- Screening/Validation
- Biologics Development
- Structure Determination
- Small Molecule Drug Development
The protein delivered can be used for these specific applications. When ordering, please indicate which applications you intend to use the protein for in the contact form to ensure the best results.
For more details, explore our solubilization database.
Datasheets
Upon ordering, you will receive the corresponding datasheets and the Certificate of Analysis (CoA).
| Feature | |
|---|---|
| Alternative names | CLDN1, CLD1, SEMP1, UNQ481/PRO944 |
| UniProt Number | O95832 |
| Protein class | Claudin |
| Original host | Homo sapiens |
| Expression system | HEK293 |
| Sequence, One-Letter Code | MANAGLQLLGFILAFLGWIGAIVSTALPQWRIYSYAGDNIVTAQAMYEGLWMSCVSQSTGQIQCKVFDSLLNLSSTLQATRALMIVGILLGVIAIFVATVGMKCMKCLEDDEVQKMRMAVIGGAIFLLAGLAILVATAWYGNRIVQEFYDPMTPVNARYEFGQALFTGWAAASLCLLGGALLCCSCPRKTTSYPTPRPYPKPAPSSGKDYVGSSGTETSQVAPA |
| Affinity tags | Rho1D4-tag (C-terminal) |
| Size (excluding additional elements) | 211 amino acids, 23 kDa |
| Concentration | 0.4 - 0.7 mg/ml |
| Purity | >90%, determined via SDS-PAGE |
| Purification process | 2-step purification |
| Shipping | Shipment is carried out on dry-ice for temperature stability to ensure the integrity of the product. |
| Function | Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (PubMed:23407391). {ECO:0000269|PubMed:23407391}.; (Microbial infection) Acts as a co-receptor for hepatitis C virus (HCV) in hepatocytes (PubMed:17325668, PubMed:20375010, PubMed:24038151). Associates with CD81 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell (PubMed:20375010). Acts as a receptor for dengue virus (PubMed:24074594). {ECO:0000269|PubMed:17325668, ECO:0000269|PubMed:20375010, ECO:0000269|PubMed:24038151, ECO:0000269|PubMed:24074594}. |
| PubMed ID | 9931503, 10828592, 11071387, 12975309, 15489334, 15521008, 16619213, 17325668, 20375010, 21269460, 21516087, 23407391, 24074594, 23704991, 24038151 |
Lab Results
