Claudin-18.2 (isoform of Claudin-18; CLDN18.2)

Order number: 70033

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Amount

Description

We are pleased to introduce our off-the-shelf, full-length, active, and native Claudin 18.2 protein, an isoform of Claudin-18 (CLDN18.2). This integral membrane protein plays a critical role in cellular adhesion and tight junction formation, making it a significant target in cancer research and drug development.

Our Claudin 18.2 protein has been solubilized and stabilized using our NativeMP™ platform, ensuring it retains its native structure and full biological activity, ideal for a variety of research applications.

Applications:

Screening/Validation
Biologics Development
Structure Determination
Small Molecule Drug Development

The protein delivered can be used for these specific applications. When ordering, please indicate which applications you intend to use the protein for in the contact form to ensure the best results.

For more details, explore our solubilization database.

copolymer vs detergents workflow — **Fig. 1:** Detergents create environments that lack native lipids, which can compromise protein function and stability. Copolymers, enable you to see and analyze these aspects within a native environment. They facilitate studying how your target interacts with its surrounding lipids, and allow assays to be conducted at body temperature.

Datasheets

Upon ordering, you will receive the corresponding datasheets and the Certificate of Analysis (CoA).

Feature
Alternative names	CLDN18.2
UniProt Number	P56856-2
Protein class	Claudin
Original host	Homo sapiens
Expression system	HEK293
Sequence, One-Letter Code	MAVTACQGLGFVVSLIGIAGIIAATCMDQWSTQDLYNNPVTAVFNYQGLWRSCVRESSGFTECRGYFTLLGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLTSGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWVAGGLTLIGGVMMCIACRGLAPEETNYKAVSYHASGHSVAYKPGGFKASTGFGSNTKNKKIYDGGARTEDEVQSYPSKHDYVGSSGTETSQVAPA
Affinity tags	Rho1D4-tag (C-terminal)
Size (excluding additional elements)	261 amino acids, 28 kDa
Concentration	0.4 - 0.7 mg/ml
Purity	>90%, determined via SDS-PAGE
Purification process	2-step purification
Shipping	Shipment is carried out on dry-ice for temperature stability to ensure the integrity of the product.
Function	Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. {ECO:0000250}.

Lab Results

CLDN18.2 Eluate +DLS — **Figure 2:** Exemplary in-house SDS-Page and DLS data of CLDN18.2 NativeMP™ copolymer screens. More in-depth data sets can be accessed upon project initiation.