Claudin-3 (CLDN3, C7orf1, CPETR2)

Order number: 70051

€12,800.00*

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Amount

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Description

We are pleased to introduce our off-the-shelf, full-length, active, and native Claudin-3 protein, also known as CLDN3, C7orf1, and CPETR2. Claudin-3 is an integral membrane protein crucial for the formation and maintenance of tight junctions, which regulate the paracellular transport between epithelial cells. It plays a significant role in various physiological processes and is implicated in diseases such as cancer and viral infections.

Our Claudin-3 protein has been solubilized and stabilized using Cube Biotech's NativeMP™ platform, ensuring it maintains its native structure and full biological activity, making it ideal for various research applications.

Applications:

Screening/Validation
Biologics Development
Structure Determination
Small Molecule Drug Development

The protein delivered can be used for these specific applications. When ordering, please indicate which applications you intend to use the protein for in the contact form to ensure the best results.

For more details, explore our solubilization database.

copolymer vs detergents workflow — **Fig. 1:** Detergents create environments that lack native lipids, which can compromise protein function and stability. Copolymers, enable you to see and analyze these aspects within a native environment. They facilitate studying how your target interacts with its surrounding lipids, and allow assays to be conducted at body temperature.

Datasheets

Upon ordering, you will receive the corresponding datasheets and the Certificate of Analysis (CoA).

Feature
Alternative names	CLDN3, C7orf1, CPETR2
UniProt Number	O15551
Protein class	Claudin
Original host	Homo sapiens
Expression system	HEK293
Sequence, One-Letter Code	MSMGLEITGTALAVLGWLGTIVCCALPMWRVSAFIGSNIITSQNIWEGLWMNCVVQSTGQMQCKVYDSLLALPQDLQAARALIVVAILLAAFGLLVALVGAQCTNCVQDDTAKAKITIVAGVLFLLAALLTLVPVSWSANTIIRDFYNPVVPEAQKREMGAGLYVGWAAAALQLLGGALLCCSCPPREKKYTATKVVYSAPRSTGPGASLGTGYDRKDYVGSSGTETSQVAPA
Affinity tags	Rho1D4-tag (C-terminal)
Size (excluding additional elements)	220 amino acids, 23 kDa
Concentration	0.4 - 0.7 mg/ml
Purity	>90%, determined via SDS-PAGE
Purification process	2-step purification
Shipping	Shipment is carried out on dry-ice for temperature stability to ensure the integrity of the product.
Function	Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. {ECO:0000250\|UniProtKB:Q9Z0G9}.
PubMed ID	9441748, 9334247, 15489334, 24275569

Lab Results

CLDN3 Eluate +DLS — **Figure 2:** Exemplary in-house SDS-Page and DLS data of CLDN3 NativeMP™ copolymer screens. More in-depth data sets can be accessed upon project initiation.