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CLDN9 - Claudin-9

Order number: 70830
CLDN9 - Claudin-9

€10,800.00*

Prices plus VAT plus shipping costs

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Description

We are excited to introduce our off-the-shelf, full-length, active, and native Claudin 9, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. In addition to its role in hepatitis C, Claudin 9 has been identified as a prognostic biomarker for endometrial cancer. Claudin 9 is associated with the preservation of sensory cells in the hearing organ, and mutations in this protein may result in hearing loss.

Our CLDN9 protein has been solubilized and stabilized using our NativeMP™ platform, ensuring it retains its native structure and full biological activity, making it ideal for various research applications.

Applications:

  • Screening/Validation
  • Biologics Development
  • Structure Determination
  • Small Molecule Drug Development

The protein delivered can be used for these specific applications. When ordering, please indicate which applications you intend to use the protein for in the contact form to ensure the best results.

For more details, explore our solubilization database.

copolymer vs detergents workflow
Fig. 1: Detergents create environments that lack native lipids, which can compromise protein function and stability. Copolymers, enable you to see and analyze these aspects within a native environment. They facilitate studying how your target interacts with its surrounding lipids, and allow assays to be conducted at body temperature.

Datasheets

Upon ordering, you will receive the corresponding datasheets and the Certificate of Analysis (CoA).
Feature
Alternative names CLDN9
UniProt Number O95484
Protein class Claudin
Original host Homo sapiens
Expression system HEK293
Sequence, One-Letter Code MASTGLELLGMTLAVLGWLGTLVSCALPLWKVTAFIGNSIVVAQVVWEGLWMSCVVQSTGQMQCKVYDSLLALPQDLQAARALCVIALLLALLGLLVAITGAQCTTCVEDEGAKARIVLTAGVILLLAGILVLIPVCWTAHAIIQDFYNPLVAEALKRELGASLYLGWAAAALLMLGGGLLCCTCPPPQVERPRGPRLGYSIPSRSGASGLDKRDYVGSSGTETSQVAPA
Affinity tags Rho1D4-tag (C-terminal)
Size (excluding additional elements) 217 amino acids, 23 kDa
Concentration 0.4 - 0.7 mg/ml
Purity >90%, determined via SDS-PAGE
Purification process 2-step purification
Shipping Shipment is carried out on dry-ice for temperature stability to ensure the integrity of the product.
Function Claudin 9 is a member of the claudin family. It is an integral membrane protein and a component of tight junction strands. In addition to its role in hepatitis C, Claudin 9 has been identified as a prognostic biomarker for endometrial cancer. Claudin 9 is associated with the preservation of sensory cells in the hearing organ, and mutations in this protein may result in hearing loss.
PubMed ID 17804490, 20375010, 31175426, 9786950, 37719361, 36129146