GIPR / GIP-R - Gastric inhibitory polypeptide receptor

Order number: 70522

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Amount

Description

We are excited to introduce our off-the-shelf, full-length, active, and native Gastric inhibitory polypeptide receptor, commonly known as GIPR. The gastric inhibitory polypeptide receptor (GIPR) is the receptor for the gastric inhibitory polypeptide (GIP), which has been identified as a key player in the process of insulin release in the presence of elevated glucose levels. This suggests a direct role for GIPR in the regulation of insulin secretion. Additionally, GIPR has been associated with the regulation of adiposity, making it a promising target for metabolic disease therapies.

Our GIPR protein has been solubilized and stabilized using our NativeMP™ platform, ensuring it retains its native structure and full biological activity, making it ideal for various research applications.

Applications:

Screening/Validation
Biologics Development
Structure Determination
Small Molecule Drug Development

The protein delivered can be used for these specific applications. When ordering, please indicate which applications you intend to use the protein for in the contact form to ensure the best results.

For more details, explore our solubilization database.

copolymer vs detergents workflow — **Fig. 1:** Detergents create environments that lack native lipids, which can compromise protein function and stability. Copolymers, enable you to see and analyze these aspects within a native environment. They facilitate studying how your target interacts with its surrounding lipids, and allow assays to be conducted at body temperature.

Datasheets

Upon ordering, you will receive the corresponding datasheets and the Certificate of Analysis (CoA).

Feature
Alternative names	Glucose-dependent insulinotropic polypeptide receptor, GIPR, GIP-R
UniProt Number	P48546
Protein class	GPCR
Subclass	Class B1 (Peptide)
Original host	Homo sapiens
Expression system	Trichoplusia ni
Sequence, One-Letter Code	MKTIIALSYIFCLVFARAETGSKGQTAGELYQRWERYRRECQETLAAAEPPSGLACNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQWGLWRDHTQCENPEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHINLFTSFMLRAAAILSRDRLLPRPGPYLGDQALALWNQALAACRTAQIVTQYCVGANYTWLLVEGVYLHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQCWERNEVKAIWWIIRTPILMTILINFLIFIRILGILLSKLRTRQMRCRDYRLRLARSTLTLVPLLGVHEVVFAPVTEEQARGALRFAKLGFEIFLSSFQGFLVSVLYCFINKEVQSEIRRGWHHCRLRRSLGEEQRQLPERAFRALPSGSGPGEVPTSRGLSSGTLPGPGNEASRELESYCGSSGTETSQVAPA
Affinity tags	HA signal peptide, Rho1D4-tag (C-terminal)
Size (excluding additional elements)	458 amino acids, 52 kDa
Concentration	0.4 - 0.7 mg/ml
Purity	>90%, determined via SDS-PAGE
Purification process	2-step purification
Shipping	Shipment is carried out on dry-ice for temperature stability to ensure the integrity of the product.
Function	The gastric inhibitory polypeptide receptor (GIPR) is the receptor for the gastric inhibitory polypeptide (GIP), which has been identified as a key player in the process of insulin release in the presence of elevated glucose levels. This suggests a direct role for GIPR in the regulation of insulin secretion. Additionally, GIPR has been associated with the regulation of adiposity, making it a promising target for metabolic disease therapies.
PubMed ID	7556958, 7589426, 8575774, 22412906, 39019866, 15057824, 38346960