SLC2A1 - Solute carrier family 2, facilitated glucose transporter member 1

Order number: 70212

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Amount (µg)

Description

We are excited to introduce our full-length, active, and native Solute carrier family 2, facilitated glucose transporter member 1 protein, encoded by SLC2A1. This essential membrane transporter is involved in moving glucose from the bloodstream into the cerebrospinal fluid, which surrounds the brain, making it a crucial target in epileptic research and neuroscience. Additionally, SLC2A1 is one of the key genes in cancer glycometabolism, which promotes the glycolysis of cancer cells, thus affecting their growth and metastasis.

Our SLC2A1 protein has been solubilized and stabilized using our NativeMP™ platform, ensuring it retains its native structure and full biological activity, ideal for a variety of research applications.

Applications:

Screening/Validation
Biologics Development
Structure Determination
Small Molecule Drug Development

The protein delivered can be used for these specific applications. When ordering, please indicate which applications you intend to use the protein for in the contact form to ensure the best results.

For more details, explore our solubilization database.

copolymer vs detergents workflow — **Fig. 1:** Detergents create environments that lack native lipids, which can compromise protein function and stability. Copolymers, enable you to see and analyze these aspects within a native environment. They facilitate studying how your target interacts with its surrounding lipids, and allow assays to be conducted at body temperature.

Datasheets

Upon ordering, you will receive the corresponding datasheets and the Certificate of Analysis (CoA).

Feature
Alternative names	SLC2A1, GLUT1
UniProt Number	P11166
Protein class	SLC transporter
Original host	Homo sapiens
Expression system	HEK293
Sequence, One-Letter Code	MEPSSKKLTGRLMLAVGGAVLGSLQFGYNTGVINAPQKVIEEFYNQTWVHRYGESILPTTLTTLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLMMNLLAFVSAVLMGFSKLGKSFEMLILGRFIIGVYCGLTTGFVPMYVGEVSPTALRGALGTLHQLGIVVGILIAQVFGLDSIMGNKDLWPLLLSIIFIPALLQCIVLPFCPESPRFLLINRNEENRAKSVLKKLRGTADVTHDLQEMKEESRQMMREKKVTILELFRSPAYRQPILIAVVLQLSQQLSGINAVFYYSTSIFEKAGVQQPVYATIGSGIVNTAFTVVSLFVVERAGRRTLHLIGLAGMAGCAILMTIALALLEQLPWMSYLSIVAIFGFVAFFEVGPGPIPWFIVAELFSQGPRPAAIAVAGFSNWTSNFIVGMCFQYVEQLCGPYVFIIFTVLLVLFFIFTYFKVPETKGRTFDEIASGFRQGGASQSDKTPEELFHPLGADSQVGSSGGSSGTETSQVAPA
Affinity tags	Rho1D4-tag (C-terminal)
Size (excluding additional elements)	492 amino acids, 54 kDa
Concentration	0.4 - 0.7 mg/ml
Purity	>90%, determined via SDS-PAGE
Purification process	2-step purification
Shipping	Shipment is carried out on dry-ice for temperature stability to ensure the integrity of the product.
Function	Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Very broad substrate specificity; can transport a wide range of aldoses including pentoses and hexoses.

Lab Results

SLC2A1 Eluate + DLS — **Figure 2:** Exemplary in-house SDS-Page and DLS data of SLC2A1 NativeMP™ copolymer screens. More in-depth data sets can be accessed upon project initiation.