ABCG2 - Broad substrate specificity ATP-binding cassette transporter

Order number: 70411

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Amount

Description

We are excited to introduce our off-the-shelf, full-length, active, and native Broat substrate specificity ATP-binding cassete transporter ABCG2, commonly known as ABCG2. ABCG2 is an ATP-binding cassette efflux transporter that plays a critical role in the cellular uptake and elimination of drugs, thereby contributing to their pharmacokinetics.

It facilitates the export of chemotherapeutic drugs from various organs and tissues, thus regulating their accumulation and subsequent elimination from the body. Additionally, ABCG2 contributes to the release of urate, an antioxidant present in the bloodstream, into the urine in the intestines. Genetic defects in ABCG2 have been associated with the development of gout.

Our ABCG2 protein has been solubilized and stabilized using our NativeMP™ platform, ensuring it retains its native structure and full biological activity, making it ideal for various research applications.

Applications:

Screening/Validation
Biologics Development
Structure Determination
Small Molecule Drug Development

The protein delivered can be used for these specific applications. When ordering, please indicate which applications you intend to use the protein for in the contact form to ensure the best results.

For more details, explore our solubilization database.

copolymer vs detergents workflow — **Fig. 1:** Detergents create environments that lack native lipids, which can compromise protein function and stability. Copolymers, enable you to see and analyze these aspects within a native environment. They facilitate studying how your target interacts with its surrounding lipids, and allow assays to be conducted at body temperature.

Datasheets

Upon ordering, you will receive the corresponding datasheets and the Certificate of Analysis (CoA).

Feature
Alternative names	ATP-binding cassette sub-family G member 2, Breast cancer resistance protein, CDw338, Mitoxantrone resistance-associated protein, Placenta-specific ATP-binding cassette transporter, Urate exporter, ABCG2FAS, APT1
UniProt Number	Q9UNQ0
Protein class	ABC transporter
Original host	Homo sapiens
Expression system	HEK293
Sequence, One-Letter Code	MSSSNVEVFIPVSQGNTNGFPATASNDLKAFTEGAVLSFHNICYRVKLKSGFLPCRKPVEKEILSNINGIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANFKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADFFLDIINGDSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKETKAELHQLSGGEKKKKITVFKEISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIGAIYFGLKNDSTGIQNRAGVLFFLTTNQCFSSVSAVELFVVEKKLFIHEYISGYYRVSSYFLGKLLSDLLPMRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIAAGQSVVSVATLLMTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFLGQNFCPGLNATGNNPCNYATCTGEEYLVKQGIDLSPWGLWKNHVALACMIVIFLTIAYLKLLFLKKYSGSSGTETSQVAPA
Affinity tags	Rho1D4-tag (C-terminal)
Size (excluding additional elements)	655 amino acids, 72 kDa (Homodimer)
Concentration	0.4 - 0.7 mg/ml
Purity	>90%, determined via SDS-PAGE
Purification process	2-step purification
Shipping	Shipment is carried out on dry-ice for temperature stability to ensure the integrity of the product.
Function	The ATP-binding cassete transporter ABCG2 is an ATP-binding cassette efflux transporter that plays a critical role in the cellular uptake and elimination of drugs, thereby contributing to their pharmacokinetics. It facilitates the export of chemotherapeutic drugs from various organs and tissues, thus regulating their accumulation and subsequent elimination from the body. Additionally, ABCG2 contributes to the release of urate, an antioxidant present in the bloodstream, into the urine in the intestines.Genetic defects in ABCG2 have been associated with the development of gout.
PubMed ID	9850061, 9861027, 11306452, 11533706, 12958161, 14702039

Lab Results

ABCG2 Eluate +DLS — **Figure 2:** Exemplary in-house SDS-Page and DLS data of ABCG2 NativeMP™ copolymer screens. More in-depth data sets can be accessed upon project initiation.