SLC15A4 - Solute carrier family 15 member 4

Order number: 70642
On Request
Ready to ship today

Description

We are excited to introduce our off-the-shelf, full-length, active, and native Solute carrier family member 4, commonly known as SLC15A4. SLC15A4 is a proton-coupled amino acid transporter that plays a critical role in the import of dipeptides across the plasma membrane, as well as the transport of peptidoglycan. It is also essential for the maintenance of homeostasis in mast cell secretory granules, a process that involves the limitation of mast cell functions and inflammatory responses. Mutations in this gene have been linked to a variety of autoimmune and inflammatory conditions, including systemic lupus erythematosus and colitis.

Our SLC15A4 protein has been solubilized and stabilized using our NativeMP™ platform, ensuring it retains its native structure and full biological activity, making it ideal for various research applications.

Applications:

  • Screening/Validation
  • Biologics Development
  • Structure Determination
  • Small Molecule Drug Development

The protein delivered can be used for these specific applications. When ordering, please indicate which applications you intend to use the protein for in the contact form to ensure the best results.

For more details, explore our solubilization database.

copolymer vs detergents workflow
Fig. 1: Detergents create environments that lack native lipids, which can compromise protein function and stability. Copolymers, enable you to see and analyze these aspects within a native environment. They facilitate studying how your target interacts with its surrounding lipids, and allow assays to be conducted at body temperature.

Datasheets

Upon ordering, you will receive the corresponding datasheets and the Certificate of Analysis (CoA).
Feature
Alternative names Peptide transporter 4, Peptide/histidine transporter 1, SLC15A4, PHT1, PTR4
UniProt Number Q8N697
Protein class SLC transporter
Original host Homo sapiens
Expression system HEK293
Sequence, One-Letter Code MEGSGGGAGERAPLLGARRAAAAAAAAGAFAGRRAACGAVLLTELLERAAFYGITSNLVLFLNGAPFCWEGAQASEALLLFMGLTYLGSPFGGWLADARLGRARAILLSLALYLLGMLAFPLLAAPATRAALCGSARLLNCTAPGPDAAARCCSPATFAGLVLVGLGVATVKANITPFGADQVKDRGPEATRRFFNWFYWSINLGAILSLGGIAYIQQNVSFVTGYAIPTVCVGLAFVVFLCGQSVFITKPPDGSAFTDMFKILTYSCCSQKRSGERQSNGEGIGVFQQSSKQSLFDSCKMSHGGPFTEEKVEDVKALVKIVPVFLALIPYWTVYFQMQTTYVLQSLHLRIPEISNITTTPHTLPAAWLTMFDAVLILLLIPLKDKLVDPILRRHGLLPSSLKRIAVGMFFVMCSAFAAGILESKRLNLVKEKTINQTIGNVVYHAADLSLWWQVPQYLLIGISEIFASIAGLEFAYSAAPKSMQSAIMGLFFFFSGVGSFVGSGLLALVSIKAIGWMSSHTDFGNINGCYLNYYFFLLAAIQGATLLLFLIISVKYDHHRDHQRSRANGVPTSRRAGSSGTETSQVAPA
Affinity tags Rho1D4-tag (C-terminal)
Size (excluding additional elements) 577 amino acids, 62 kDa
Concentration 0.4 - 0.7 mg/ml
Purity >90%, determined via SDS-PAGE
Purification process 2-step purification
Shipping Shipment is carried out on dry-ice for temperature stability to ensure the integrity of the product.
Function The solute carrier family member 4 is a proton-coupled amino acid transporter that plays a critical role in the import of dipeptides across the plasma membrane, as well as the transport of peptidoglycan. It is also essential for the maintenance of homeostasis in mast cell secretory granules, a process that involves the limitation of mast cell functions and inflammatory responses. Mutations in this gene have been linked to a variety of autoimmune and inflammatory conditions, including systemic lupus erythematosus and colitis.
PubMed ID 15498874, 11741232, 11741260, 16289537, 23186163, 25238095, 29224352, 31073693