Sulfo-Cubipol Medium
Order number: 19011
Description
Welcome the new addition to our NativeMP™ Platform: The Cubipol Series.
The proprietary Cubipol backbone, developed in-house, condenses the positive effects of previously available backbones like SMA, DIBMA, and Ultrasolute™ Amphipol. This new development delivers a new multimodal copolymer backbone, making the Cubipol series the first commercially available next-generation copolymer with 8 available off-the-shelf modified variants.
It joins the Next Generation Copolymers AASTY and Ultrasolute™ Amphipol, making solubilization and stabilization of membrane proteins a simpler and more effective endeavor than ever before.
Screening is key to discovering the best copolymer to stabilize your membrane protein target. Try the copolymers individually or save time by screening once and identifying the best stabilizing copolymers for your specific application with our NativeMP™ Screening Kit.
The proprietary Cubipol backbone, developed in-house, condenses the positive effects of previously available backbones like SMA, DIBMA, and Ultrasolute™ Amphipol. This new development delivers a new multimodal copolymer backbone, making the Cubipol series the first commercially available next-generation copolymer with 8 available off-the-shelf modified variants.
It joins the Next Generation Copolymers AASTY and Ultrasolute™ Amphipol, making solubilization and stabilization of membrane proteins a simpler and more effective endeavor than ever before.
Screening is key to discovering the best copolymer to stabilize your membrane protein target. Try the copolymers individually or save time by screening once and identifying the best stabilizing copolymers for your specific application with our NativeMP™ Screening Kit.
Sulfo-Cubipol Medium
The low charged, zwitterionic copolymer variation resembles softer surfactants with a high resistance to extreme pH values, ionic strength and divalent ion concentrations (details in the table below). It belongs to the Cubipol class with low charge, which allows for the uninterrupted study of charge-sensitive interactions between membrane proteins and lipids.The Sulfo-Cubipol series offers three versions—Lite, Medium, and Standard—each with varying levels of sulfobetaine functionalization to enhance hydrophilicity. Adjusting these properties optimizes stabilization and purification of membrane proteins for sensitive applications like cryo-TEM.
Explore the other sulfo variants Sulfo-Cubipol and Sulfo Cubipol Lite.
Datasheets
| Feature | |
|---|---|
| State | Lyophilized Powder, to be solved with water |
| Full Name | Sulfo-Cubipol Medium |
| Buffer | HEPES |
| pH after solving | 7.5 |
| pH Stability of Copolymer | 5.5-10 |
| Absorbance at 280nm | No |
| Molecular Weight | 11,7 kDA |
| Ca2+ tolerance | 40 mM |
| Mg2+ tolerance | 40 mM |
| Solubility | > 10% (H2O) |
| Polymerization Type | Free-Radical |
| Shipping Temperature | Ambient Temparature |
| Storage of lyophilized copolymer | -20°C for several years |
| Storage of dissolved copolymer | 2-8°C for several days |
Video
Watch this video and let Dr. Philipp Hanisch explain why you need to work with our NativeMP™ Copolymer Nanodiscs
Disclaimer
Patent Pending
The product described above has been developed and produced by Cube Biotech GmbH. Our products are intended for molecular applications. These products are not intended for diagnosis, prevention or treatment of a disease.
The product described above has been developed and produced by Cube Biotech GmbH. Our products are intended for molecular applications. These products are not intended for diagnosis, prevention or treatment of a disease.