New Application Note with Nanotemper's Monolith X

We’re continuing to work closely with NanoTemper Technolgies to highlight the best technologies for membrane protein research and how to pair them for optimal results.

Membrane proteins are central to drug discovery but present unique challenges for biophysical characterization. Many traditional methods disrupt their native structure, making interaction studies difficult and unreliable. That’s where Cube Biotech’s NativeMP™ Technology and NanoTemper’s Monolith X come in.

➡ Detergent-free stabilization – NativeMP™ uses synthetic nanodiscs to maintain the integrity of membrane proteins
➡ High-sensitivity interaction analysis – Monolith X leverages Spectral Shift & TRIC for ultra-precise binding affinity measurements
➡ Minimal sample requirements – Ideal for working with challenging membrane protein targets
➡ No immobilization needed – Directly measure interactions in solution with any buffer composition


This workflow empowers you to study protein-small molecule, protein-peptide, and protein-protein interactions with unprecedented accuracy and ease. Whether you’re investigating GPCRs, ion channels, or transporters, this technology ensures faster, more reliable drug discovery—without the limitations of detergents and the loss of functional stability in your membrane proteins.

Visit our product page to explore how NativeMP™ can support your projects, and download the app note to learn more about this approach!