Potassium channel Kv1.3 (KCNA3, HGK5)

Order number: 70111

€14,800.00*

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Description

Introducing our off-the-shelf, full-length, active, and native Potassium Channel K_v1.3 protein, also known as KCNA3 or HGK5. This voltage-dependent potassium channel is crucial for immune response, particularly in T cells, where it plays a key role in cell activation. The channel mediates potassium (K⁺) ion efflux, which is essential for membrane repolarization during T cell activation and proliferation. Modulating K_v1.3 activity has significant implications for immune suppression and autoimmune disease research.

Our K_v1.3 protein has been solubilized and stabilized using Cube Biotech's NativeMP™ platform, ensuring it retains its native structure and full biological activity, making it ideal for various research applications.

Applications:

Screening/Validation
Biologics Development
Structure Determination
Small Molecule Drug Development

The protein delivered can be used for these specific applications. When ordering, please indicate which applications you intend to use the protein for in the contact form to ensure the best results.

For more details, explore our solubilization database.

copolymer vs detergents workflow — **Fig. 1:** Detergents create environments that lack native lipids, which can compromise protein function and stability. Copolymers, enable you to see and analyze these aspects within a native environment. They facilitate studying how your target interacts with its surrounding lipids, and allow assays to be conducted at body temperature.

Datasheets

Upon ordering, you will receive the corresponding datasheets and the Certificate of Analysis (CoA).

Feature
Alternative names	KCNA3, HGK5
UniProt Number	P22001
Protein class	Ion channel
Original host	Homo sapiens
Expression system	HEK293
Sequence, One-Letter Code	MDERLSLLRSPPPPPSARHRAHPPQRPASSGGAHTLVNHGYAEPAAGRELPPDMTVVPGDHLLEPEVADGGGAPPQGGCGGGGCDRYEPLPPSLPAAGEQDCCGERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASTSQDSFEAAGNSTSGSRAGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADDPTSGFSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQSQYMHVGSCQHLSSAELRKARSNSTLSKSEYMVIEEGGMNHSAFPQTPFKTGNSTATCTTNNNPNSCVNIKKIFTDVGSSGTETSQVAPA
Affinity tags	Rho1D4-tag (C-terminal)
Size (excluding additional elements)	575 amino acids, 64 kDa (forms Homotetramers)
Concentration	0.4 - 0.7 mg/ml
Purification process	2-step purification
Shipping	Shipment is carried out on dry-ice for temperature stability to ensure the integrity of the product.
Function	Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
PubMed ID	7829094, 16710414, 15489334, 1986382, 1373731, 1547020

Lab Results

KCNA3 Eluate +DLS — **Figure 2:** Exemplary in-house SDS-Page and DLS data of KCNA3 NativeMP™ copolymer screens. More in-depth data sets can be accessed upon project initiation.