Go to homepage
Global
USA
Cart
Buy also at
Buy also at

CB2 - Cannabinoid receptor 2

Order number: 70461
CB2 - Cannabinoid receptor 2

€12,800.00*

Prices plus VAT plus shipping costs

Ready to ship today
Quantity

Description

We are excited to introduce our off-the-shelf, full-length, active, and native Cannabinoid receptor 2, commonly known as CB2. Similar to CB1, this protein is a G-protein coupled receptor. CB2 has the potential as a therapeutic target for neurodegenerative conditions, e.g. Alzheimer's disease and for neuropathic pain.

Our CB2 protein has been solubilized and stabilized using our NativeMP™ platform, ensuring it retains its native structure and full biological activity, making it ideal for various research applications.

Applications:

  • Screening/Validation
  • Biologics Development
  • Structure Determination
  • Small Molecule Drug Development

The protein delivered can be used for these specific applications. When ordering, please indicate which applications you intend to use the protein for in the contact form to ensure the best results.

For more details, explore our solubilization database.

copolymer vs detergents workflow
Fig. 1: Detergents create environments that lack native lipids, which can compromise protein function and stability. Copolymers, enable you to see and analyze these aspects within a native environment. They facilitate studying how your target interacts with its surrounding lipids, and allow assays to be conducted at body temperature.

Datasheets

Upon ordering, you will receive the corresponding datasheets and the Certificate of Analysis (CoA).
Feature
Alternative names CB-2, CB2, hCB2FAS, CX5, CNR2
UniProt Number P34972
Protein class GPCR
Subclass Class A (Lipid)
Organism Human (Homo sapiens)
Expression system Trichoplusia ni
Sequence, One-Letter CodeMKTIIALSYIFCLVFADYKDDDDKEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDCGSSGTETSQVAPA
Affinity tags HA signal peptide, FLAG-tag (N-terminal); Rho1D4-tag (C-terminal)
Size (excluding additional elements) 380 amino acids, 42 kDa
Concentration 0.4 - 0.7 mg/ml
Purity >90%, determined via SDS-PAGE
Purification process 2-step purification
Shipping Shipment is carried out on dry-ice for temperature stability to ensure the integrity of the product.
Function The cannabinoid receptor 2 (CB2) is a G-protein coupled receptor, which is similar to the CB1 receptor. CB2 has been identified as a potential therapeutic target for neurodegenerative conditions, including Alzheimer's disease, and for neuropathic pain.
PubMed ID 7689702, 19496827, 7556170, 10400664

Citations