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CD37 - Leukocyte antigen CD37

Order number: 70952
CD37 - Leukocyte antigen CD37
On Request
Ready to ship today
On Request

Description

We are excited to introduce our off-the-shelf, full-length, active, and native Leukocyte antigen CD37, commonly known as C37, which is a B-cell surface antigen that plays a crucial role in mediating the interaction between T-cells and B-cells. This antigen functions as a surface receptor and has been implicated in the development of acute myeloid leukaemia (AML), thus establishing it as a viable therapeutic target.

Our CD37 protein has been solubilized and stabilized using our NativeMP™ platform, ensuring it retains its native structure and full biological activity, making it ideal for various research applications.

Applications:

  • Screening/Validation
  • Biologics Development
  • Structure Determination
  • Small Molecule Drug Development

The protein delivered can be used for these specific applications. When ordering, please indicate which applications you intend to use the protein for in the contact form to ensure the best results.

For more details, explore our solubilization database.

copolymer vs detergents workflow
Fig. 1: Detergents create environments that lack native lipids, which can compromise protein function and stability. Copolymers, enable you to see and analyze these aspects within a native environment. They facilitate studying how your target interacts with its surrounding lipids, and allow assays to be conducted at body temperature.

Datasheets

Upon ordering, you will receive the corresponding datasheets and the Certificate of Analysis (CoA).
Feature
Alternative names CD37, TSPAN26, Tetraspanin-26 (Tspan-26)
UniProt Number P11049
Protein class Transporter
Original host Homo sapiens
Expression system HEK293
Sequence, One-Letter Code MSAQESCLSLIKYFLFVFNLFFFVLGSLIFCFGIWILIDKTSFVSFVGLAFVPLQIWSKVLAISGIFTMGIALLGCVGALKELRCLLGLYFGMLLLLFATQITLGILISTQRAQLERSLRDVVEKTIQKYGTNPEETAAEESWDYVQFQLRCCGWHYPQDWFQVLILRGNGSEAHRVPCSCYNLSATNDSTILDKVILPQLSRLGHLARSRHSADICAVPAESHIYREGCAQGLQKWLHNNLISIVGICLGVGLLELGFMTLSIFLCRNLDHVYNRLARYRGSSGTETSQVAPA
Affinity tags Rho1D4-tag (C-terminal)
Size (excluding additional elements) 281 amino acids, 32 kDa
Concentration 0.4 - 0.7 mg/ml
Purity >90%, determined via SDS-PAGE
Purification process 2-step purification
Shipping Shipment is carried out on dry-ice for temperature stability to ensure the integrity of the product.
Function Leukocyte antigen CD37, commonly known as C37, abbreviated C37 is a B-cell surface antigen that plays a crucial role in mediating the interaction between T-cells and B-cells. This antigen functions as a surface receptor and has been implicated in the development of acute myeloid leukaemia (AML), thus establishing it as a viable therapeutic target.
PubMed ID 2466944, 2388030, 17182550, 22624718, 26784544

Citations