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MCOLN3 - Mucolipin-3

Order number: 70673
MCOLN3 - Mucolipin-3
On Request
Product is being restocked
On Request

Description

We are excited to introduce our off-the-shelf, full-length, active, and native Mucolipin-3, commonly known as MCOLN3. This protein is a TRPMC channel, which is involved in the regulation of membrane trafficking as well as the regulation of intercellular Ca2+ signaling and it mediates the release of Ca2+ from endosomes into the cytoplasm and contributes to endosomal acidification. It is also permeable to further cations, such as Mg2+, Na2+ and K+. Furthermore, MCOLN3 contributes to autophagosome biogenesis. Mutations in this gene have been associated with deafness.

Our MCOLN3 protein has been solubilized and stabilized using our NativeMP™ platform, ensuring it retains its native structure and full biological activity, making it ideal for various research applications.

Applications:

  • Screening/Validation
  • Biologics Development
  • Structure Determination
  • Small Molecule Drug Development

The protein delivered can be used for these specific applications. When ordering, please indicate which applications you intend to use the protein for in the contact form to ensure the best results.

For more details, explore our solubilization database.

copolymer vs detergents workflow
Fig. 1: Detergents create environments that lack native lipids, which can compromise protein function and stability. Copolymers, enable you to see and analyze these aspects within a native environment. They facilitate studying how your target interacts with its surrounding lipids, and allow assays to be conducted at body temperature.

Datasheets

Upon ordering, you will receive the corresponding datasheets and the Certificate of Analysis (CoA).
Feature
Alternative names Transient receptor potential channel mucolipin 3, TRPML3, MCOLN3
UniProt Number Q8TDD5
Protein class Ion channel
Original host Homo sapiens
Expression system HEK293
Sequence, One-Letter Code MADPEVVVSSCSSHEEENRCNFNQQTSPSEELLLEDQMRRKLKFFFMNPCEKFWARGRKPWKLAIQILKIAMVTIQLVLFGLSNQMVVAFKEENTIAFKHLFLKGYMDRMDDTYAVYTQSDVYDQLIFAVNQYLQLYNVSVGNHAYENKGTKQSAMAICQHFYKRGNIYPGNDTFDIDPEIETECFFVEPDEPFHIGTPAENKLNLTLDFHRLLTVELQFKLKAINLQTVRHQELPDCYDFTLTITFDNKAHSGRIKISLDNDISIRECKDWHVSGSIQKNTHYMMIFDAFVILTCLVSLILCIRSVIRGLQLQQEFVNFFLLHYKKEVSVSDQMEFVNGWYIMIIISDILTIIGSILKMEIQAKSLTSYDVCSILLGTSTMLVWLGVIRYLGFFAKYNLLILTLQAALPNVIRFCCCAAMIYLGYCFCGWIVLGPYHDKFRSLNMVSECLFSLINGDDMFATFAKMQQKSYLVWLFSRIYLYSFISLFIYMILSLFIALITDTYETIKQYQQDGFPETELRTFISECKDLPNSGKYRLEDDPPVSLFCCCKKGSSGTETSQVAPA
Affinity tags Rho1D4-tag (C-terminal)
Size (excluding additional elements) 553 amino acids, 64 kDa (forms Homotetramers)
Concentration 0.4 - 0.7 mg/ml
Purity >90%, determined via SDS-PAGE
Purification process 2-step purification
Shipping Shipment is carried out on dry-ice for temperature stability to ensure the integrity of the product.
Function Mucolipin-3 is a TRPMC channel, which is invovled in the regulation of membrane trafficking as well as the regulation of intercellular Ca2+ signalling and it mediates the release of Ca2+ from endosomes into the cytoplasm and contributes to endosomal acidification. It is also permeable to further cations, such as Mg2+, Na2+ and K+. Furthermroe, MCOLN3 contributes to autophagosome biogenesis. Mutatiohns in this gene have been associated with deafness.
PubMed ID 18369318, 19497048, 19522758, 20378547, 19885840, 21245134, 23469151

Citations