SLC17A6 - Vesicular glutamate transporter 2

Order number: 71114

On Request

Product is being restocked

Amount (µg)

Description

We are excited to introduce our off-the-shelf, full-length, active, and native vesicular glutamate transporter 2, commonly known as SLC17A6. It is primarily found in brain and brainstem neurons, as well as in the enteric nervous system, and plays a vital role in excitatory signaling. SLC17A6 transports L-glutamate along with multiple ions such as chloride, proton, potassium, sodium and phosphate. It is of significant therapeutic interest in areas such as Parkinson’s disease and nociception and represents a relevant drug target for enhancing various brain functions.

Our SLC17A6 protein has been solubilized and stabilized using our NativeMP™ platform, ensuring it retains its native structure and full biological activity, making it ideal for various research applications.

Applications:

Screening/Validation
Biologics Development
Structure Determination
Small Molecule Drug Development

The protein delivered can be used for these specific applications. When ordering, please indicate which applications you intend to use the protein for in the contact form to ensure the best results.

For more details, explore our solubilization database.

copolymer vs detergents workflow — **Fig. 1:** Detergents create environments that lack native lipids, which can compromise protein function and stability. Copolymers, enable you to see and analyze these aspects within a native environment. They facilitate studying how your target interacts with its surrounding lipids, and allow assays to be conducted at body temperature.

Datasheets

Upon ordering, you will receive the corresponding datasheets and the Certificate of Analysis (CoA).

Feature

Alternative names

SLC17A6, Vesicular glutamate transporter 2, Solute carrier family 17 member 6, VGluT2

UniProt Number

Q9P2U8

Protein class

SLC transporter

Original host

Homo sapiens

Expression system

HEK293

Sequence, One-Letter Code

MESVKQRILAPGKEGLKNFAGKSLGQIYRVLEKKQDTGETIELTEDGKPLEVPERKAPLCDCTCFGLPRRYIIAIMSGLGFCISFGIRCNLGVAIVDMVNNSTIHRGGKVIKEKAKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAARVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVWYMFWLLVSYESPAKHPTITDEERRYIEESIGESANLLGAMEKFKTPWRKFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQILSTTTVRKIMNCGGFGMEATLLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKNKSREEWQYVFLIAALVHYGGVIFYAIFASGEKQPWADPEETSEEKCGFIHEDELDEETGDITQNYINYGTTKSYGATTQANGGWPSGWEKKEEFVQGEVQDSHSYKDRVDYSGSSGTETSQVAPA

Affinity tags

Rho1D4-tag (C-terminal)

Size (excluding additional elements)

595 amino acids, 66 kDa

Concentration

0.4 - 0.7 mg/ml

Purity

>90%, determined via SDS-PAGE

Purification process

2-step purification

Shipping

Shipment is carried out on dry-ice for temperature stability to ensure the integrity of the product.

Function

SLC17A6 is responsible for loading the neurotransmitter glutamate into synaptic vesicles. This process is essential for glutamate release during synaptic transmission. SLC17A6 transports L-glutamate along with multiple ions such as chloride, proton, potassium, sodium and phosphate. It is of significant therapeutic interest in areas such as Parkinson’s disease and nociception and represents a relevant drug target for enhancing various brain functions.

PubMed ID

10820226, 11698620, 33440152, 8632143, 34994539

SLC17A6 - Vesicular glutamate transporter 2

Description

Datasheets

Citations