ABCB6 - ATP-binding cassette sub-family B member 6
Description
We are excited to introduce our off-the-shelf, full-length, active, and native ATP-binding cassete sub-family B member 6, commonly known as ABCB6. This transporter contributes to the regulation of the heme biosynthetic pathway by tranporting a range of porphyrins and their precursors in an ATP-dependent manner. it is located at the outer mitochondrial membrane, the plasma membrane, and lysosomal/endo-lysosomal compartments and plays a role in porphyrin homeostasis, cellular stress adaptation, and detoxification processes. Although not universally required for heme biosynthesis, it helps regulate intracellular porphyrin levels and influences cellular sensitivity to oxidative stress, xenobiotics, and toxic metal exposure.
Our ABCB6 protein has been solubilized and stabilized using our NativeMP™ platform, ensuring it retains its native structure and full biological activity, making it ideal for various research applications.
Applications:
- Screening/Validation
- Biologics Development
- Structure Determination
- Small Molecule Drug Development
The protein delivered can be used for these specific applications. When ordering, please indicate which applications you intend to use the protein for in the contact form to ensure the best results.
For more details, explore our solubilization database.
Datasheets
| Feature | |
|---|---|
| Alternative names | ABC-type heme transporter, ABCB6, MTABC3, ATP-binding cassette sub-family B member 6 |
| UniProt Number | Q9NP58 |
| Protein class | ABC transporter |
| Original host | Homo sapiens |
| Expression system | HEK293 |
| Sequence, One-Letter Code | MVTVGNYCEAEGPVGPAWMQDGLSPCFFFTLVPSTRMALGTLALVLALPCRRRERPAGADSLSWGAGPRISPYVLQLLLATLQAALPLAGLAGRVGTARGAPLPSYLLLASVLESLAGACGLWLLVVERSQARQRLAMGIWIKFRHSPGLLLLWTVAFAAENLALVSWNSPQWWWARADLGQQVQFSLWVLRYVVSGGLFVLGLWAPGLRPQSYTLQVHEEDQDVERSQVRSAAQQSTWRDFGRKLRLLSGYLWPRGSPALQLVVLICLGLMGLERALNVLVPIFYRNIVNLLTEKAPWNSLAWTVTSYVFLKFLQGGGTGSTGFVSNLRTFLWIRVQQFTSRRVELLIFSHLHELSLRWHLGRRTGEVLRIADRGTSSVTGLLSYLVFNVIPTLADIIIGIIYFSMFFNAWFGLIVFLCMSLYLTLTIVVTEWRTKFRRAMNTQENATRARAVDSLLNFETVKYYNAESYEVERYREAIIKYQGLEWKSSASLVLLNQTQNLVIGLGLLAGSLLCAYFVTEQKLQVGDYVLFGTYIIQLYMPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPLRFQKGRIEFENVHFSYADGRETLQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIHDAIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQASLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQQGQEETSEDTKPQTMERGSSGTETSQVAPA |
| Affinity tags | Rho1D4-tag (C-terminal) |
| Size (excluding additional elements) | 855 amino acids, 2x 95 kDa (Homodimer) |
| Concentration | 0.4 - 0.7 mg/mL |
| Purity | >90%, determined via SDS-PAGE |
| Purification process | 2-step purification |
| Shipping | Shipment is carried out on dry-ice for temperature stability to ensure the integrity of the product. |
| Function | ABCB6 transports porphyrins and their precursors, contributing to porphyrin and heme matebolism. ABCB6 variants define the Langereis (Land) blood group and have been associated with altered porphyrin metabolism, sensitivty to oxidative stress, and several disorders, like ocular coloboma and familial pseudohyperkalemia. |
| PubMed ID | 10837493, 11955620 |
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