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CD4 - T-cell surface glycoprotein CD4

Order number: 70711
CD4 - T-cell surface glycoprotein CD4

€10,800.00*

Prices plus VAT plus shipping costs

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Description

We are excited to introduce our off-the-shelf, full-length, active, and native T-cell surface glycoprotein CD4, which is commonly known as CD4. It is a glycoprotein involved in the immune response and cell-mediated immunity. T lymphocytes that carry the CD4 surface antigen are called T helper cells and are the subtype of T lymphocytes that are primarily infected by HIV. It is therefore a target for HIV infection and immunotherapy.

Our CD4 protein has been solubilized and stabilized using our NativeMP™ platform, ensuring it retains its native structure and full biological activity, making it ideal for various research applications.

Applications:

  • Screening/Validation
  • Biologics Development
  • Structure Determination
  • Small Molecule Drug Development

The protein delivered can be used for these specific applications. When ordering, please indicate which applications you intend to use the protein for in the contact form to ensure the best results.

For more details, explore our solubilization database.

copolymer vs detergents workflow
Fig. 1: Detergents create environments that lack native lipids, which can compromise protein function and stability. Copolymers, enable you to see and analyze these aspects within a native environment. They facilitate studying how your target interacts with its surrounding lipids, and allow assays to be conducted at body temperature.

Datasheets

Upon ordering, you will receive the corresponding datasheets and the Certificate of Analysis (CoA).
Feature
Alternative names T-cell surface antigen T4/Leu-3, CD4
UniProt Number P01730
Protein class Receptor
Original host Homo sapiens
Expression system HEK293
Sequence, One-Letter Code MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASSIVYKKEGEQVEFSFPLAFTVEKLTGSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEVNLVVMRATQLQKNLTCEVWGPTSPKLMLSLKLENKEAKVSKREKAVWVLNPEAGMWQCLLSDSGQVLLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQAERMSQIKRLLSEKKTCQCPHRFQKTCSPIGSSGTETSQVAPA
Affinity tags Rho1D4-tag (C-terminal)
Size (excluding additional elements) 458 amino acids, 51 kDa (Homodimer)
Concentration 0.4 - 0.7 mg/ml
Purity >90%, determined via SDS-PAGE
Purification process 2-step purification
Shipping Shipment is carried out on dry-ice for temperature stability to ensure the integrity of the product.
Function The T-cell surface glycoprotein CD4 is a glycoprotein involved in the immune response and cell-mediated immunity. T lymphocytes that carry the CD4 surface antigen are called T helper cells and are the subtype of T lymphocytes that are primarily infected by HIV. It is therefore a target for HIV infection and immunotherapy.
PubMed ID 2990730, 3263213, 8723724, 9074930, 1708753, 1425921

Citations

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