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SLC1A4 - Neutral amino acid transporter A​

Order number: 71591
SLC1A4 - Neutral amino acid transporter A​

€12,800.00*

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Description

We are excited to introduce our off-the-shelf, full-length, active, and native Neutral amino acid transporter A​, commonly known as SLC1A4. SLC1A4 is a sodium-coupled antiporter of neutral amino acids that operates via a tri-substrate transport cycle, exchanging neutral amino acids between the extracellular and intracellular compartments, coupled with the inward cotransport of at least one sodium ion. It plays a key role in amino acid homeostasis and is particularly important for serine transport in the brain. Loss-of-function mutations in SLC1A4 cause an autosomal recessive neurodevelopmental disorder characterized by developmental delay, microcephaly, and hypomyelination.
Our SLC1A4 protein has been solubilized and stabilized using our NativeMP™ platform, ensuring it retains its native structure and full biological activity, making it ideal for various research applications.

Applications:

  • Screening/Validation
  • Biologics Development
  • Structure Determination
  • Small Molecule Drug Development

The protein delivered can be used for these specific applications. When ordering, please indicate which applications you intend to use the protein for in the contact form to ensure the best results.

For more details, explore our solubilization database.

copolymer vs detergents workflow
Fig. 1: Detergents create environments that lack native lipids, which can compromise protein function and stability. Copolymers, enable you to see and analyze these aspects within a native environment. They facilitate studying how your target interacts with its surrounding lipids, and allow assays to be conducted at body temperature.

Datasheets

Upon ordering, you will receive the corresponding datasheets and the Certificate of Analysis (CoA).
Feature
Alternative names SLC1A4, Neutral amino acid transporter A, Solute carrier family 1 member 4, ASCT1
UniProt Number P43007
Protein class SLC transporter
Original host Homo sapiens
Expression system HEK293
Sequence, One-Letter Code MEKSNETNGYLDSAQAGPAAGPGAPGTAAGRARRCAGFLRRQALVLLTVSGVLAGAGLGAALRGLSLSRTQVTYLAFPGEMLLRMLRMIILPLVVCSLVSGAASLDASCLGRLGGIAVAYFGLTTLSASALAVALAFIIKPGSGAQTLQSSDLGLEDSGPPPVPKETVDSFLDLARNLFPSNLVVAAFRTYATDYKVVTQNSSSGNVTHEKIPIGTEIEGMNILGLVLFALVLGVALKKLGSEGEDLIRFFNSLNEATMVLVSWIMWYVPVGIMFLVGSKIVEMKDIIVLVTSLGKYIFASILGHVIHGGIVLPLIYFVFTRKNPFRFLLGLLAPFATAFATCSSSATLPSMMKCIEENNGVDKRISRFILPIGATVNMDGAAIFQCVAAVFIAQLNNVELNAGQIFTILVTATASSVGAAGVPAGGVLTIAIILEAIGLPTHDLPLILAVDWIVDRTTTVVNVEGDALGAGILHHLNQKATKKGEQELAEVKVEAIPNCKSEEETSPLVTHQNPAGPVASAPELESKESVLGSSGTETSQVAPA
Affinity tags Rho1D4-tag (C-terminal)
Size (excluding additional elements) 545 amino acids, 3x 57 kDa
Concentration 0.4 - 0.7 mg/mL
Purity >90%, determined via SDS-PAGE
Purification process 2-step purification
Shipping Shipment is carried out on dry-ice for temperature stability to ensure the integrity of the product.
Function SLC1A4 is involved in the transport of neutral amino acids, particularly serine, across cell membranes, supporting amino acid homeostasis and neurotransmission in the brain. Mutations in this gene are linked to an autosomal recessive neurodevelopmental disorder characterized by developmental delay, microcephaly, and hypomyelination.
PubMed ID 8101838, 8340364, 8910405, 24808181, 27272177

Citations

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