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SLC20A2 - Sodium-dependent phosphate transporter 2

Order number: 71771
SLC20A2 - Sodium-dependent phosphate transporter 2

€12,800.00*

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Description

We are excited to introduce our off-the-shelf, full-length, active, and native Sodium-dependent phosphate transporter 2, commonly known as SLC20A2. SLC20A2 is primarily responsible for maintaining cellular phosphate homeostasis by transporting inorganic phosphate across plasma membranes.  Dysfunctional mutations in this gene are a leading cause of Primary Familial Brain Calcification, as impaired phosphate transport leads to calcium phosphate deposits in the basal ganglia and other brain regions.

Our SLC20A2 protein has been solubilized and stabilized using our NativeMP™ platform, ensuring it retains its native structure and full biological activity, making it ideal for various research applications.

Applications:

  • Screening/Validation
  • Biologics Development
  • Structure Determination
  • Small Molecule Drug Development

The protein delivered can be used for these specific applications. When ordering, please indicate which applications you intend to use the protein for in the contact form to ensure the best results.

For more details, explore our solubilization database.

copolymer vs detergents workflow
Fig. 1: Detergents create environments that lack native lipids, which can compromise protein function and stability. Copolymers, enable you to see and analyze these aspects within a native environment. They facilitate studying how your target interacts with its surrounding lipids, and allow assays to be conducted at body temperature.

Datasheets

Upon ordering, you will receive the corresponding datasheets and the Certificate of Analysis (CoA).
Feature
Alternative names PIT2, GLVR2, Gibbon ape leukemia virus receptor 2, Phosphate transporter 2
UniProt Number Q08357
Protein class SLC transporter
Original host Homo sapiens
Expression system HEK293
Sequence, One-Letter Code MAMDEYLWMVILGFIIAFILAFSVGANDVANSFGTAVGSGVVTLRQACILASIFETTGSVLLGAKVGETIRKGIIDVNLYNETVETLMAGEVSAMVGSAVWQLIASFLRLPISGTHCIVGSTIGFSLVAIGTKGVQWMELVKIVASWFISPLLSGFMSGLLFVLIRIFILKKEDPVPNGLRALPVFYAATIAINVFSIMYTGAPVLGLVLPMWAIALISFGVALLFAFFVWLFVCPWMRRKITGKLQKEGALSRVSDESLSKVQEAESPVFKELPGAKANDDSTIPLTGAAGETLGTSEGTSAGSHPRAAYGRALSMTHGSVKSPISNGTFGFDGHTRSDGHVYHTVHKDSGLYKDLLHKIHIDRGPEEKPAQESNYRLLRRNNSYTCYTAAICGLPVHATFRAADSSAPEDSEKLVGDTVSYSKKRLRYDSYSSYCNAVAEAEIEAEEGGVEMKLASELADPDQPREDPAEEEKEEKDAPEVHLLFHFLQVLTACFGSFAHGGNDVSNAIGPLVALWLIYKQGGVTQEAATPVWLLFYGGVGICTGLWVWGRRVIQTMGKDLTPITPSSGFTIELASAFTVVIASNIGLPVSTTHCKVGSVVAVGWIRSRKAVDWRLFRNIFVAWFVTVPVAGLFSAAVMALLMYGILPYVGSSGTETSQVAPA
Affinity tags Rho1D4-tag (C-terminal)
Size (excluding additional elements) 665 amino acids, 72 kDa
Concentration 0.4 - 0.7 mg/mL
Purity >90%, determined via SDS-PAGE
Purification process 2-step purification
Shipping Shipment is carried out on dry-ice for temperature stability to ensure the integrity of the product.
Function The solute carrier family 20 member 2 is a sodium-dependent inorganic phosphate cotransporter that plays a critical role in maintaining cellular phosphate homeostasis by mediating the transport of Pi across plasma membranes. It is also essential for the regulation of mineral deposition in the brain, a process that involves preventing the pathological accumulation of calcium phosphate in the vascular extracellular matrix. Mutations in this gene have been linked to primary familial brain calcification, a neurodegenerative condition characterized by bilateral deposits in the basal ganglia and other cerebral regions.
PubMed ID 39121859, 38195526, 35881308, 25726928

Citations

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