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SLC2A2 - Solute carrier family 2, facilitated glucose transporter member 2

Order number: 70631
SLC2A2 - Solute carrier family 2, facilitated glucose transporter member 2

€10,800.00*

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Description

We are excited to introduce our off-the-shelf, full-length, active, and native Solute carrier family 2, commonly known as SLC2A2. This protein facilitates the hexose transport of glucose, fructose, and galactose. It has been demonstrated to mediate facilitated bidirectional glucose transport with a low affinity for glucose, suggesting a glucose sensor function, particularly in the liver and the pancreas. Mutations in this gene have been associated with an increased susceptibility to diseases, including Fanconi-Bickel syndrome and non-insulin-dependent diabetes mellitus.

Our SLC2A2 protein has been solubilized and stabilized using our NativeMP™ platform, ensuring it retains its native structure and full biological activity, making it ideal for various research applications.

Applications:

  • Screening/Validation
  • Biologics Development
  • Structure Determination
  • Small Molecule Drug Development

The protein delivered can be used for these specific applications. When ordering, please indicate which applications you intend to use the protein for in the contact form to ensure the best results.

For more details, explore our solubilization database.

copolymer vs detergents workflow
Fig. 1: Detergents create environments that lack native lipids, which can compromise protein function and stability. Copolymers, enable you to see and analyze these aspects within a native environment. They facilitate studying how your target interacts with its surrounding lipids, and allow assays to be conducted at body temperature.

Datasheets

Upon ordering, you will receive the corresponding datasheets and the Certificate of Analysis (CoA).
Feature
Alternative names Glucose transporter type 2, SLC2A2, GLUT2
UniProt Number P11168
Protein class SLC transporter
Original host Homo sapiens
Expression system HEK293
Sequence, One-Letter Code MTEDKVTGTLVFTVITAVLGSFQFGYDIGVINAPQQVIISHYRHVLGVPLDDRKAINNYVINSTDELPTISYSMNPKPTPWAEEETVAAAQLITMLWSLSVSSFAVGGMTASFFGGWLGDTLGRIKAMLVANILSLVGALLMGFSKLGPSHILIIAGRSISGLYCGLISGLVPMYIGEIAPTALRGALGTFHQLAIVTGILISQIIGLEFILGNYDLWHILLGLSGVRAILQSLLLFFCPESPRYLYIKLDEEVKAKQSLKRLRGYDDVTKDINEMRKEREEASSEQKVSIIQLFTNSSYRQPILVALMLHVAQQFSGINGIFYYSTSIFQTAGISKPVYATIGVGAVNMVFTAVSVFLVEKAGRRSLFLIGMSGMFVCAIFMSVGLVLLNKFSWMSYVSMIAIFLFVSFFEIGPGPIPWFMVAEFFSQGPRPAALAIAAFSNWTCNFIVALCFQYIADFCGPYVFFLFAGVLLAFTLFTFFKVPETKGKSFEEIAAEFQKKSGSAHRPKAAVEMKFLGATETVGSSGTETSQVAPA
Affinity tags Rho1D4-tag (C-terminal)
Size (excluding additional elements) 524 amino acids, 57 kDa
Concentration 0.4 - 0.7 mg/ml
Purity >90%, determined via SDS-PAGE
Purification process 2-step purification
Shipping Shipment is carried out on dry-ice for temperature stability to ensure the integrity of the product.
Function The solute carrier family 2 facilitates the hexose transport of glucose, fructose and galactose. It has been demonstrated to mediate facilitated bidirectional glucose transport with a low affinity for glucose, suggesting a glucose sensor function, particularly in the liver and the pancreas. Mutations in this gene have been associated with an increased susceptibility to diseases, including Fanconi-Bickel syndrome and non-insulin-dependent diabetes mellitus.
PubMed ID 3399500, 7593414, 8457197, 16186102, 23396969, 24275569, 28083649

Citations

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