AASTY

Poly(acrylic acid-co-styrene), AASTY or SAA, is a highly-alternating copolymer, well-suited for the generation of native lipid nanodiscs. The reactivity ratios of styrene and acrylic acid, allow for a more alternating monomer sequence in the polymer, than 2:1 SMA copolymers. AASTY is developed by Anton Autzen and Henriette Autzen, in a collaboration between the Appel Research Group at Stanford University, and the Yifan Cheng Lab at the University of California San Francisco. AASTY has been found to be superior in the extraction of membrane proteins compared to SMA, across multiple systems.

Recommended publicationsSmith et al. 2020 & Timcenko et al. 2022