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DRD1 - D(1) dopamine receptor

Order number: 70181
DRD1 - D(1) dopamine receptor

€12,800.00*

Prices plus VAT plus shipping costs

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Description

We are excited to introduce our off-the-shelf, full-length, active, and native D(1) dopamine receptor, commonly known as DRD1. This G-protein coupled receptor inhibits adenylyl cyclase activity and is involved in reward-mediating mesocorticolimbic pathways. DRD1 has been also associated with schizophrenia and moreover it is the main receptor for many antipsychotic drugs.

Our DRD1 protein has been solubilized and stabilized using our NativeMP™ platform, ensuring it retains its native structure and full biological activity, making it ideal for various research applications.

Applications:

  • Screening/Validation
  • Biologics Development
  • Structure Determination
  • Small Molecule Drug Development

The protein delivered can be used for these specific applications. When ordering, please indicate which applications you intend to use the protein for in the contact form to ensure the best results.

For more details, explore our solubilization database.

copolymer vs detergents workflow
Fig. 1: Detergents create environments that lack native lipids, which can compromise protein function and stability. Copolymers, enable you to see and analyze these aspects within a native environment. They facilitate studying how your target interacts with its surrounding lipids, and allow assays to be conducted at body temperature.

Datasheets

Upon ordering, you will receive the corresponding datasheets and the Certificate of Analysis (CoA).
Feature
Alternative names DRD1, Dopamine D1 receptor
UniProt Number P21728
Protein class GPCR
Original host Homo sapiens
Expression system Trichoplusia ni
Sequence, One-Letter Code MKTIIALSYIFCLVFADYKDDDDKENLYFQGRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPTGSSGTETSQVAPA
Affinity tags HA signal peptide, DYKDDDK-tag, TEV cleavage site (N-terminal); Rho1D4-tag (C-terminal)
Size (excluding additional elements) 473 amino acids, 52 kDa
Concentration 0.4 - 0.7 mg/ml
Purity >90%, determined via SDS-PAGE
Purification process 2-step purification
Shipping Shipment is carried out on dry-ice for temperature stability to ensure the integrity of the product.
Function The Dopamine Receptor D1 (DRD1) mediates essential functions in motor control, reward, and cognition by stimulating cAMP production in the brain. Its therapeutic relevance lies in managing Parkinson’s disease and cognitive impairment, where selective targeting helps restore neurological balance with fewer side effects than non-selective treatments..
PubMed ID 33571432, 35789850, 33456556, 37048120, 39129007

Citations

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