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GCGR - Glucagon receptor

Order number: 70511
GCGR - Glucagon receptor

€10,800.00*

Prices plus VAT plus shipping costs

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Description

We are excited to introduce our off-the-shelf, full-length, active, and native Glucagon receptor, commonly known as GCGR. The glucoagon receptor plays a key role in the regulation of blood glucose levels and glucose homeostasis, as well as promoting glycogen hydrolysis and gluconeogenesis by regulating the rate of hepatic glucose. It is therefore a potential target for the treatment of diabetes and other metabolic disorders.

Our GCGR protein has been solubilized and stabilized using our NativeMP™ platform, ensuring it retains its native structure and full biological activity, making it ideal for various research applications.

Applications:

  • Screening/Validation
  • Biologics Development
  • Structure Determination
  • Small Molecule Drug Development

The protein delivered can be used for these specific applications. When ordering, please indicate which applications you intend to use the protein for in the contact form to ensure the best results.

For more details, explore our solubilization database.

copolymer vs detergents workflow
Fig. 1: Detergents create environments that lack native lipids, which can compromise protein function and stability. Copolymers, enable you to see and analyze these aspects within a native environment. They facilitate studying how your target interacts with its surrounding lipids, and allow assays to be conducted at body temperature.

Datasheets

Upon ordering, you will receive the corresponding datasheets and the Certificate of Analysis (CoA).
Feature
Alternative names GCGR, GL-R
UniProt Number P47871
Protein class GPCR
Subclass Class A (Lipid)
Expression system Trichoplusia ni
Organism Human (Homo sapiens)
Sequence, One-Letter Code MKTIIALSYIFCLVFADYKDDDDKAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPFGSSGTETSQVAPA
Affinity tags HA signal peptide, FLAG-tag (N-terminal); Rho1D4-tag (C-terminal)
Size (excluding additional elements) 473 amino acids, 53 kDa
Residues 26-477
Concentration 0.4 - 0.7 mg/ml
Purity >90%, determined via SDS-PAGE
Purification process 2-step purification
Shipping Shipment is carried out on dry-ice for temperature stability to ensure the integrity of the product.
Function The Glucagon receptor plays a key role in the regulation of blood glucose levels and glucose homeostasis, as well as promoting glycogen hydrolysis and gluconeogenesis by regulating the rate of hepatic glucose. It is therefore a potential target for the treatment of diabetes and other metabolic disorders.
PubMed ID 7507321, 8144028, 8020989, 9287038, 24275569, 16221670

Citations

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