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LPAR3 - Lysophosphatidic acid receptor 3

Order number: 71831
LPAR3 - Lysophosphatidic acid receptor 3

€12,800.00*

Prices plus VAT plus shipping costs

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Description

We are excited to introduce our off-the-shelf, full-length, active, and native Lysophosphatidic acid receptor 3, commonly known as LPAR3. It is a G-protein coupled receptor that binds the extracellular lipid mediator lysophosphatidic acid (LPA).  It is widely expressed in human tissues, with particularly high density in the heart, reproductive system (prostate, testes, uterus), brain, and gastrointestinal tract.

Our LPAR3 protein has been solubilized and stabilized using our NativeMP™ platform, ensuring it retains its native structure and full biological activity, making it ideal for various research applications.

Applications:

  • Screening/Validation
  • Biologics Development
  • Structure Determination
  • Small Molecule Drug Development

The protein delivered can be used for these specific applications. When ordering, please indicate which applications you intend to use the protein for in the contact form to ensure the best results.

For more details, explore our solubilization database.

copolymer vs detergents workflow
Fig. 1: Detergents create environments that lack native lipids, which can compromise protein function and stability. Copolymers, enable you to see and analyze these aspects within a native environment. They facilitate studying how your target interacts with its surrounding lipids, and allow assays to be conducted at body temperature.

Datasheets

Upon ordering, you will receive the corresponding datasheets and the Certificate of Analysis (CoA).
Feature
Alternative names LPAR3, LPA-3, LPA receptor 3
UniProt Number Q9UBY5
Protein class GPCR
Subclass Class A (Lipid)
Original host Homo sapiens
Expression system Trichoplusia ni
Sequence, One-Letter Code MKTIIALSYIFCLVFANECHYDKHMDFFYNRSNTDTVDDWTGTKLVIVLCVGTFFCLFIFFSNSLVIAAVIKNRKFHFPFYYLLANLAAADFFAGIAYVFLMFNTGPVSKTLTVNRWFLRQGLLDSSLTASLTNLLVIAVERHMSIMRMRVHSNLTKKRVTLLILLVWAIAIFMGAVPTLGWNCLCNISACSSLAPIYSRSYLVFWTVSNLMAFLIMVVVYLRIYVYVKRKTNVLSPHTSGSISRRRTPMKLMKTVMTVLGAFVVCWTPGLVVLLLDGLNCRQCGVQHVKRWFLLLALLNSVVNPIIYSYKDEDMYGTMKKMICCFSQENPERRPSRIPSTVLSRSDTGSQYIEDSISQGAVCNKSTSGSSGTETSQVAPA
Affinity tags HA signal peptide, Rho1D4-tag (C-terminal)
Size (excluding additional elements) 353 amino acids, 41 kDa
Concentration 0.4 - 0.7 mg/mL
Purity >90%, determined via SDS-PAGE
Purification process 2-step purification
Shipping Shipment is carried out on dry-ice for temperature stability to ensure the integrity of the product.
Function LPAR3 is a Class A GPCR that preferentially binds unsaturated lysophosphatidic acid to drive intracellular calcium release, cell migration, and survival through G<sub>q/11</sub> and G<sub>i/o</sub> signaling. It is an active therapeutic target in oncology to prevent cancer invasion and metastasis, as well as in neurodegenerative disorders and reproductive biology.
PubMed ID 32755608, 17199132, 31090079

Citations

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