Go to homepage
Global
USA
Cart
Buy also at
Buy also at

S1PR4 - Sphingosine 1-phosphate receptor 4

Order number: 71751
S1PR4 - Sphingosine 1-phosphate receptor 4

€12,800.00*

Prices plus VAT plus shipping costs

Ready to ship today
Quantity

Description

We are excited to introduce our off-the-shelf, full-length, active, and native Sphingosine 1-phosphate receptor 4, commonly known as S1PR4. This protein is a G-protein coupled receptor for signaling lipid sphingosine-1-phosphate.  S1PR4 acts as a molecular switch that influences how immune cells move and mature. This has therapeutic relevance in Multiple Sclerosis and other related immune diseases.

Our S1PR4 protein has been solubilized and stabilized using our NativeMP™ platform, ensuring it retains its native structure and full biological activity, making it ideal for various research applications.

Applications:

  • Screening/Validation
  • Biologics Development
  • Structure Determination
  • Small Molecule Drug Development

The protein delivered can be used for these specific applications. When ordering, please indicate which applications you intend to use the protein for in the contact form to ensure the best results.

For more details, explore our solubilization database.

copolymer vs detergents workflow
Fig. 1: Detergents create environments that lack native lipids, which can compromise protein function and stability. Copolymers, enable you to see and analyze these aspects within a native environment. They facilitate studying how your target interacts with its surrounding lipids, and allow assays to be conducted at body temperature.

Datasheets

Upon ordering, you will receive the corresponding datasheets and the Certificate of Analysis (CoA).
Feature
Alternative names S1P4, S1P receptor 4, EDG6, Endothelial differentiation G-protein coupled receptor 6
UniProt Number O95977
Protein class GPCR
Subclass Class A (Lipid)
Organism Human (Homo sapiens)
Expression system Trichoplusia ni
Sequence, One-Letter Code MKTIIALSYIFCLVFADYKDDDDKNATGTPVAPESCQQLAAGGHSRLIVLHYNHSGRLAGRGGPEDGGLGALRGLSVAASCLVVLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWFLREGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGMLPLLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGAIFRLVQASGQKAPRPAARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWILALAVLNSAVNPIIYSFRSREVCRAVLSFLCCGCLRLGMRGPGDCLARAVEAHSGASTTDSSLRPRDSFRGSRSLSFRMREPLSSISSVRSIGSSGTETSQVAPA
Affinity tags HA signal peptide, FLAG-tag (N-terminal); Rho1D4-tag (C-terminal)
Size (excluding additional elements) 396 amino acids, 43 kDa
Concentration 0.4 - 0.7 mg/mL
Purity >90%, determined via SDS-PAGE
Purification process 2-step purification
Shipping Shipment is carried out on dry-ice for temperature stability to ensure the integrity of the product.
Function S1PR4 is a signaling protein located on the surface of immune and blood-forming cells that controls their movement and maturation by responding to specific lipid signals. By managing the recruitment of inflammatory cells and the production of platelets, it serves as a precise target for therapies aimed at treating autoimmune disorders and cancer without impacting other organ systems.
PubMed ID 40915360, 40342995, 32017036, 32278039, 36789612

Citations

X