SLC46A1 - Proton-coupled folate transporter
Order number: 71431
Description
We are excited to introduce our off-the-shelf, full-length, active, and native Proton-coubled folate transporter, as known as SLC46A1. SLC46A1 is a proton-coupled folate transporter that mediates the uptake of folate across the intestinal epithelium and its transport into tissues. Functions as a symporter that transports folate together with protons, enabling efficient absorption under acidic conditions.
Our SLC46A1 protein has been solubilized and stabilized using Cube Biotech's NativeMP™ platform, ensuring it retains its native structure and full biological activity, making it ideal for a wide range of research applications.
Applications:
- Screening/Validation
- Biologics Development
- Structure Determination
- Small Molecule Drug Development
The protein delivered can be used for these specific applications. When ordering, please indicate which applications you intend to use the protein for in the contact form to ensure the best results.
For more details, explore our solubilization database.
Datasheets
Upon ordering, you will receive the corresponding datasheets and the Certificate of Analysis (CoA).
| Feature | |
|---|---|
| Alternative names | SLC46A1, Proton-coupled folate transporter, HsPCFT, hPCFT, Heme carrier protein 1 |
| UniProt ID | Q96NT5 |
| Protein class | SLC transporter |
| Original host | Homo sapiens |
| Expression system | HEK293 |
| Sequence, One-Letter Code | MEGSASPPEKPRARPAAAVLCRGPVEPLVFLANFALVLQGPLTTQYLWHRFSADLGYNGTRQRGGCSNRSADPTMQEVETLTSHWTLYMNVGGFLVGLFSSTLLGAWSDSVGRRPLLVLASLGLLLQALVSVFVVQLQLHVGYFVLGRILCALLGDFGGLLAASFASVADVSSSRSRTFRMALLEASIGVAGMLASLLGGHWLRAQGYANPFWLALALLIAMTLYAAFCFGETLKEPKSTRLFTFRHHRSIVQLYVAPAPEKSRKHLALYSLAIFVVITVHFGAQDILTLYELSTPLCWDSKLIGYGSAAQHLPYLTSLLALKLLQYCLADAWVAEIGLAFNILGMVVFAFATITPLMFTGYGLLFLSLVITPVIRAKLSKLVRETEQGALFSAVACVNSLAMLTASGIFNSLYPATLNFMKGFPFLLGAGLLLIPAVLIGMLEKADPHLEFQQFPQSPPGSSGTETSQVAPA |
| Affinity tags | Rho1D4-tag (C-terminal) |
| Size (excluding additional elements) | 472 amino acids, 51 kDa |
| Concentration | 0.4 - 0.7 mg/mL |
| Purity | >90%, determined via SDS-PAGE |
| Purification process | 2-step purification |
| Shipping | Shipment is carried out on dry-ice for temperature stability to ensure the integrity of the product. |
| Function | SLC46A1 is a proton-coupled folate transporter that mediates the uptake of folate across the intestinal epithelium and its transport into tissues. Functions as a symporter that transports folate together with protons, enabling efficient absorption under acidic conditions. |
| PubMed ID | 17129779, 17156779, 17446347, 17475902, 18524888 |
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