AASTY


Poly(acrylic acid-co-styrene), AASTY or SAA, is a highly-alternating copolymer, well-suited for the generation of native lipid nanodiscs. The reactivity ratios of styrene and acrylic acid, allow for a more alternating monomer sequence in the polymer, than 2:1 SMA copolymers.
 

Features - Our Individual AASTYs in comparison

Things to know in before:
  • Ratio of Acrylic Acid to Styrene - 45:55, 50:50 or 55:45 | Acrylic Acid contributes to hydrophilic property of AASTY
  • 5-6 kDa more aggressive; 10-11 kDa thermodynamic stable | Acrylic Acid contributes to charge


NameMolecular WeightpH after solvingDivalent cationic toleranceAcrylic Acid : Styrene Ratio
AASTY 6-45 5-6 kDa 7.5 6 mM 45% to 55%
AASTY 6-50 5-6 kDa 7.5 6 mM 50% to 50%
AASTY 6-55 5-6 kDa 7.5 6 mM 55% to 45%
AASTY 11-45 10-11 kDa 7.5 6 mM 45% to 55%
AASTY 11-50 10-11 kDa 7.5 6 mM 50% to 50%
AASTY 11-55 10-11 kDa 7.5 6 mM 55% to 45%


AASTY development

AASTY is developed by Anton Autzen and Henriette Autzen, in a collaboration between the Appel Research Group at Stanford University, and the Yifan Cheng Lab at University of California San Francisco. AASTY have been found to be superior in extraction of membrane proteins compared to SMA, across multiple systems.

The exact composition of AASTY copolymers show different extraction efficiency, depending on the lipid composition of the lipid bilayers being formulated into nanodiscs.

As AASTY is made by controlled radical polymerization techniques, the dispersity of polymer molecular weight distribution is low, and the molecular weights are controlled. This means that excess AASTY copolymer can be removed by dialysis after nanodisc formation.

Based on previous findings on SMA, it is the expectation that AASTY of different molecular weights will display different rates of nanodisc formation, extraction efficacy, and stability of resulting nanodiscs.
NanodiscAnton Autzen NanodiscHenriette Autzen

We recommend the two following publications about AASTYs if you like to have more information:

 
Top seller
PolyHunter PolyHunter
Article number: 19103
AASTY 11-50 AASTY 11-50
Article number: 18265
Tube containing AASTY 6-55 AASTY 6-55
Article number: 18270
AASTY 6-45 by Cube Biotech AASTY 6-45
Article number: 18250
Tube containing AASTY 11-45 AASTY 11-45
Article number: 18255
Vial containing AASTY 6-50 AASTY 6-50
Article number: 18260
AASTY
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Overview of all Synthetic polymers that are contained in the MAXI screening Kit Synthetic Nanodisc Screening Kit MAXI (16x2x50 mg)
Not sure what type of synthetic nanodisc is best for your membrane protein? Use our MAXI screening kit to find out.
Article number: 18295
Sales price: $702.00 * $780.00 *
PolyHunter PolyHunter
For the depletion of remaining free copolymers like AASTY or DIBMA.
Article number: 19103
Sales price: From $102.00 *
AASTY 11-50 AASTY 11-50
AASTY 11-50 is the one of the more aggressive polymers for membrane proteins stabilization. Find out more!
Article number: 18265
Sales price: From $250.80 *
AASTY Screening Kit Contents AASTY Screening Kit (6x2x50 mg)
Not sure which AASTY fits your membrane protein the best? Our AASTY Screening Kit exists to answer this question!
Article number: 18285
Sales price: $277.20 *
Tube containing AASTY 6-55 AASTY 6-55
AASTY 6-55 is the one of the more aggressive polymers for membrane proteins stabilization. Find out more!
Article number: 18270
Sales price: From $250.80 *
AASTY 6-45 by Cube Biotech AASTY 6-45
AASTY 6-45 is the one of the more aggressive polymers for membrane proteins stabilization. Find out more!
Article number: 18250
Sales price: From $250.80 *
Tube containing AASTY 11-45 AASTY 11-45
AASTY 11-45 is the one of the more aggressive polymers for membrane proteins stabilization. Find out more!
Article number: 18255
Sales price: From $250.80 *
Vial containing AASTY 6-50 AASTY 6-50
AASTY 6-50 is the one of the more aggressive polymers for membrane proteins stabilization. Find out more!
Article number: 18260
Sales price: From $250.80 *
Tube Containing AASTY 11-55 AASTY 11-55
AASTY 11-55 is the one of the more aggressive polymers for membrane proteins stabilization. Find out more!
Article number: 18275
Sales price: From $250.80 *
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